The fascia can be defined as a dynamic highly complex connective tissue network
composed of different types of cells embedded in the extracellular matrix and nervous fibers …

Dupuytren disease is a benign, progressive fibroproliferative disorder of the hands. To date,
only one pharmacotherapy (clostridial collagenase) has been approved for use in …

Dupuytren's disease is a progressive fibroproliferative disorder of the hand. In the nodular
stage of Dupuytren's disease, pain might limit daily hand activities and progress to finger …

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Dupuytren disease is a fibroproliferative disorder of the palmar fascia of the hand. Little
agreement and remarkable variability exists in treatment algorithms between surgeons …

Background Dupuytren's disease (DD) is a progressive, debilitating condition of the hand
that can eventually cause contractures of the affected fingers. Transforming growth factor-β1 …

Introduction The partial aponeurectomy for treatment of Dupuytren's contracture represents
the gold standard for treatment of Dupuytren's contracture. In selected cases, the alternative …

Dupuytren disease is a progressive, benign fibroproliferative disorder of the hands that can
lead to debilitating hand contractures. Once symptomatic, treatment involves either surgical …

Purpose Although European genome-wide association studies (GWAS) have aided in
defining genetic associations in Dupuytren disease (DD), North American populations have …

(1) Background: genetic variations, localized in the functional regions of the extracellular
matrix (ECM) modulation-related genes, may alter the transcription process and impact the …