Efficient whole-cell biosynthesis of (S)-2-chloro-1-(3, 4-difluorophenyl)-ethanol from 2-chloro-1-(3, 4-difluorophenyl) ethanone in a sustainable reaction system

L Kong, B Fan, YC He - Molecular Catalysis, 2023 - Elsevier
Abstract (S)-2-Chloro-1-(3, 4-difluorophenyl)-ethanol [(S)-CFPL] is a key chiral intermediate
in the manufacture of Ticagrelor. In this study, deep eutectic solvent (DES) was used as the …

Advancements in biocatalysis: A comprehensive review of applications in organic synthesis

V Nayak, G Jude Martis, SL Gaonkar - Synthetic Communications, 2025 - Taylor & Francis
Biocatalysis is an essential tool in the green synthesis of compounds. These catalysts exhibit
regioselectivity and stereoselectivity toward specific products, enabling nontoxic and eco …

Optimized enantioselective (S)-2-hydroxypropiophenone synthesis by free- and encapsulated-resting cells of Pseudomonas putida

R Kordesedehi, MA Asadollahi, A Shahpiri, D Biria… - Microbial Cell …, 2023 - Springer
Background Aromatic α-hydroxy ketones, such as S-2-hydroxypropiophenone (2-HPP), are
highly valuable chiral building blocks useful for the synthesis of various pharmaceuticals …

Efficient bioreduction of 1-(furan-2-yl) ethanone into enantiomerically pure drug precursor by Lactobacillus paracasei BD101

E Şahin - Molecular Catalysis, 2023 - Elsevier
Asymmetric bioreduction catalyzed by biocatalyst have shown considerable potential in the
preparation of chiral alcohols.(R)-1-(furan-2-yl) ethanol ((R)-2) can be used precursor in the …

Engineered Alcaligenes sp. by chemical mutagen produces thermostable and acido-alkalophilic endo-1,4-β-mannanases for improved industrial biocatalyst

OO Olaniyi, AS Ajulo, OT Lawal… - Preparative Biochemistry …, 2023 - Taylor & Francis
This study reported physicochemical properties of purified endo-1, 4-β-mannanase from the
wild type, Alcaligenes sp. and its most promising chemical mutant. The crude enzymes from …

Hypouricemic, anti-inflammatory, and antioxidant activities of Lactobacillus-based functional yogurt in induced-arthritic male Wistar rats: Therapeutic and protective …

AN El-Dein, A Ezzat, HF Aly, EA Younis… - Biocatalysis and …, 2023 - Elsevier
Hyperuricemia is the increased serum uric acid concentration, associated with metabolic
syndrome that commonly leads to heart disease, gout, and chronic nephropathy. In animals …

Development of an enzymatic process for the synthesis of (1S)-2-chloro-1-(3, 4-difluorophenyl) ethanol, the key intermediate of ticagrelor

C Che, W Zhang, Y Men, H Li, B Qin, X Jia, S You - Molecular Catalysis, 2023 - Elsevier
Asymmetric bioreductions catalyzed by ketoreductases have shown considerable potential
in the synthesis of chiral alcohols. However, the synthesis routes of (1S)-2-chloro-1-(3, 4 …

Enzymatic Synthesis of Indole‐Based Imidazopyridine using α‐Amylase

P Kamboj, V Tyagi - ChemBioChem, 2024 - Wiley Online Library
Abstract The imidazo [1, 2‐a] pyridine scaffold has gained significant attention due to its
presence as a lead structure in several commercially available pharmaceuticals like …

Efficient Biosynthesis of (S)-1-chloro-2-heptanol Catalyzed by a Newly Isolated Fungi Curvularia hominis B-36

S Xu, Q Lin, W Chen, R Lin, Y Shen, P Tang, S Yu… - Catalysts, 2022 - mdpi.com
(S)-1-chloro-2-heptanol is an enantiopure chemical of great value that can synthesize
Treprostinil for treating primary pulmonary hypertension. In this work, a new strain B-36 …

Biocatalytic asymmetric synthesis of secondary allylic alcohols using Burkholderia cepacia lipase immobilized on multiwalled carbon nanotubes

MRG Dias, GPC da Silva, A de Pauloveloso… - Chirality, 2022 - Wiley Online Library
The lipase from Burkholderia cepacia (BCL) was immobilized through physical adsorption
on pristine and functionalized multiwalled carbon nanotubes (MWCNTs) with carboxyl or …