Abstract The interleukin-17 (IL-17) family comprises six members (IL-17A–17F), and
recently, all of its related receptors have been discovered. IL-17 was first discovered …

Signal transducer and activator of transcription (STAT) proteins compose a family of
transcription factors critical for cancer stem cells (CSCs), and they are involved in …

Tumor extracellular matrix (ECM) not only forms a physical barrier for T cells infiltration, but
also regulates multiple immunosuppressive pathways, which is an important reason for …

Liquid biopsies have emerged as a minimally invasive cancer detection and monitoring
method, which could identify cancer-related alterations in nucleosome or histone levels and …

Immune effector cells in the microenvironment tend to be depleted or remodeled, unable to
perform normal functions, and even promote the malignant characterization of tumors …

Cachexia, a debilitating condition that worsens patient outcomes, often accompanies gastric
cancer, a malignancy that is prevalent worldwide. The extensive research explored the …

Cancer remains a serious burden in society and while the pace in the development of novel
and more effective therapeutics is increasing, testing platforms that faithfully mimic the tumor …

Introduction: Signal transducer and activator of transcriptions (STATs) factors as critical
proteins in cell signaling regulate diverse biological processes such as differentiation and …

Cytokines, which are important to the tumor microenvironment (TME), play critical roles in
tumor development, metastasis, and immune responses. Interleukin-17 (IL-17) has emerged …

Sepsis-associated acute liver injury (SALI) is an independent risk for sepsis-induced death
orchestrated by innate and adaptive immune responses. Here, we found that Roquin-1 was …