Quantitative susceptibility mapping (QSM): decoding MRI data for a tissue magnetic biomarker
In MRI, the main magnetic field polarizes the electron cloud of a molecule, generating a
chemical shift for observer protons within the molecule and a magnetic susceptibility …
chemical shift for observer protons within the molecule and a magnetic susceptibility …
Iron and chelation in biochemistry and medicine: new approaches to controlling iron metabolism and treating related diseases
GJ Kontoghiorghes, CN Kontoghiorghe - Cells, 2020 - mdpi.com
Iron is essential for all living organisms. Many iron-containing proteins and metabolic
pathways play a key role in almost all cellular and physiological functions. The diversity of …
pathways play a key role in almost all cellular and physiological functions. The diversity of …
Targeting chelatable iron as a therapeutic modality in Parkinson's disease
Aims: The pathophysiological role of iron in Parkinson's disease (PD) was assessed by a
chelation strategy aimed at reducing oxidative damage associated with regional iron …
chelation strategy aimed at reducing oxidative damage associated with regional iron …
A delicate balance: Iron metabolism and diseases of the brain
Iron is the most abundant transition metal within the brain, and is vital for a number of
cellular processes including neurotransmitter synthesis, myelination of neurons, and …
cellular processes including neurotransmitter synthesis, myelination of neurons, and …
[HTML][HTML] Parkinson's disease: alterations in iron and redox biology as a key to unlock therapeutic strategies
A plethora of studies indicate that iron metabolism is dysregulated in Parkinson's disease
(PD). The literature reveals well-documented alterations consistent with established dogma …
(PD). The literature reveals well-documented alterations consistent with established dogma …
The 'swallow tail'appearance of the healthy nigrosome–a new accurate test of Parkinson's disease: a case-control and retrospective cross-sectional MRI study at 3T
There is no well-established in vivo marker of nigral degeneration in Parkinson's disease
(PD). An ideal imaging marker would directly mirror the loss of substantia nigra …
(PD). An ideal imaging marker would directly mirror the loss of substantia nigra …
The relevance of iron in the pathogenesis of Parkinson's disease
J Sian‐Hülsmann, S Mandel… - Journal of …, 2011 - Wiley Online Library
J. Neurochem.(2011) 118, 939–957. Abstract Alterations of iron levels in the brain has been
observed and documented in a number of neurodegenerative disorders including …
observed and documented in a number of neurodegenerative disorders including …
Region‐specific disturbed iron distribution in early idiopathic P arkinson's disease measured by quantitative susceptibility mapping
N He, H Ling, B Ding, J Huang, Y Zhang… - Human brain …, 2015 - Wiley Online Library
In Parkinson's disease (PD), iron elevation in specific brain regions as well as selective loss
of dopaminergic neurons is a major pathologic feature. A reliable quantitative measure of …
of dopaminergic neurons is a major pathologic feature. A reliable quantitative measure of …
Brain iron metabolism dysfunction in Parkinson's disease
H Jiang, J Wang, J Rogers, J Xie - Molecular neurobiology, 2017 - Springer
Dysfunction of iron metabolism, which includes its uptake, storage, and release, plays a key
role in neurodegenerative disorders, including Parkinson's disease (PD), Alzheimer's …
role in neurodegenerative disorders, including Parkinson's disease (PD), Alzheimer's …