The acquisition of a motile and invasive phenotype is an important step in the development
of tumors and ultimately metastasis. This step requires the abrogation of cell–cell contacts …

Recent cadherin studies focusing on cellular signaling have shown that several pathways
are activated by cadherin-mediated cell–cell contact. Cadherin-mediated contacts activate …

Commitment of stem cells to different lineages is regulated by many cues in the local tissue
microenvironment. Here we demonstrate that cell shape regulates commitment of human …

Serum response factor (SRF) regulates transcription of many serum-inducible and muscle-
specific genes. Using a functional screen, we identified LIM kinase-1 as a potent activator of …

The genetic basis of myotonic dystrophy type 1 (DM1) is a CTG expansion in the 3′
untranslated region (UTR) of DMPK. The pathogenic mechanism involves an RNA gain of …

Mature adipocytes and myocytes are derived from a common mesenchymal precursor.
While IGF-1 promotes the differentiation of both cell types, the signaling pathways that …

The muscle regulators MyoD and Myf-5 control cell cycle withdrawal and induction of
differentiation in skeletal muscle cells. By immunofluorescence analysis, we show that MyoD …

Satellite cells from adult rat muscle coexpress proliferating cell nuclear antigen and MyoD
upon entry into the cell cycle, suggesting that MyoD plays a role during the recruitment of …

N-cadherin, a member of the Ca2+-dependent cell–cell adhesion molecule family, plays an
essential role in skeletal muscle cell differentiation. We show that inhibition of N-cadherin …

The activity of serum response factor (SRF), an essential transcription factor in mouse
gastrulation, is regulated by changes in actin dynamics. Using Srf (−/−) embryonic stem (ES) …