Production of secondary metabolites using tissue culture-based biotechnological applications

II Ozyigit, I Dogan, A Hocaoglu-Ozyigit… - Frontiers in Plant …, 2023 - frontiersin.org
Plants are the sources of many bioactive secondary metabolites which are present in plant
organs including leaves, stems, roots, and flowers. Although they provide advantages to the …

Mushrooms as future generation healthy foods

V Bell, C Silva, J Guina, TH Fernandes - Frontiers in Nutrition, 2022 - frontiersin.org
The potential of edible mushrooms as an unexploited treasure trove, although rarely
included in known food guidelines, is highlighted. Their role in shielding people against the …

Pentacyclic triterpenoid phytochemicals with anticancer activity: Updated studies on mechanisms and targeted delivery

M Nistor, D Rugina, Z Diaconeasa, C Socaciu… - International Journal of …, 2023 - mdpi.com
Pentacyclic triterpenoids (TTs) represent a unique family of phytochemicals with interesting
properties and pharmacological effects, with some representatives, such as betulinic acid …

The haplotype-resolved genome assembly of autotetraploid rhubarb Rheum officinale provides insights into its genome evolution and massive accumulation of …

H Zhang, Q He, L Xing, R Wang, Y Wang, Y Liu… - Plant …, 2024 - cell.com
Rheum officinale, a member of the Polygonaceae family, is an important medicinal plant that
is widely used in traditional Chinese medicine. Here, we report a 7.68-Gb chromosome …

Structural and catalytic insight into the unique pentacyclic triterpene synthase TwOSC

Y Luo, X Ma, Y Qiu, Y Lu, S Shen, Y Li… - Angewandte Chemie …, 2023 - Wiley Online Library
The oxidosqualene cyclase (OSC) catalyzed cyclization of the linear substrate (3S)‐2, 3‐
oxidosqualene to form diverse pentacyclic triterpenoid (PT) skeletons is one of the most …

Nanocarrier mediated co-delivery of phytochemicals and chemo-drugs: An emerging strategy to combat lung cancer in a systemic way

P Upadhyay, A Ghosh, V Sarangthem… - Phytochemistry Reviews, 2024 - Springer
Lung cancer is listed as one of the hotfooted malignancies on the basis of mortality and
morbidity. Thus, emergence of new targeting and immunotherapies is being recognized that …

Triterpenes as potential drug candidates for rheumatoid arthritis treatment

C Faustino, L Pinheiro, N Duarte - Life, 2023 - mdpi.com
Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease characterized by
joint inflammation, swelling and pain. Although RA mainly affects the joints, the disease can …

Holistic quality evaluation of Hibisci Mutabilis Folium by integrating UPLC–QTOF–MS/MS chemical profiling and UPLC–TQ–MS/MS quantification approaches

CY Wu, YY Guo, J Zhou, F Long, W Zhang… - … of Pharmaceutical and …, 2022 - Elsevier
In present study, an integrating UPLC–QTOF–MS/MS chemical profiling and UPLC–TQ–
MS/MS quantification strategy was developed for the holistic quality evaluation of Hibisci …

Unraveling the role of cytochrome P450 enzymes in oleanane triterpenoid biosynthesis in arjuna tree

G Srivastava, P Vyas, A Kumar, A Singh… - The Plant …, 2024 - Wiley Online Library
SUMMARY Triterpenoids (C30‐isoprenoids) represent a major group of natural products
with various physiological functions in plants. Triterpenoids and their derivatives have …

Triterpene derivatives as potential inhibitors of the RBD spike protein from SARS-CoV-2: an in silico approach

M Avelar, L Pedraza-González, A Sinicropi… - Molecules, 2023 - mdpi.com
The appearance of a new coronavirus, SARS-CoV-2, in 2019 kicked off an international
public health emergency. Although rapid progress in vaccination has reduced the number of …