Tyrosinase is a multi-copper enzyme which is widely distributed in different organisms and
plays an important role in the melanogenesis and enzymatic browning. Therefore, its …

Arbutin is a compound of hydroquinone and D-glucose, and it has been over 30 years since
there have been serious studies on the skin lightening action of this substance. In the …

Controlling unwanted hyperpigmentation is a major challenge in dermatology and
cosmetology, and safe and efficacious antimelanogenic agents are deemed useful for this …

Tyrosinase is the rate-limiting enzyme of melanin production and, accordingly, is the most
prominent target for inhibiting hyperpigmentation. Numerous tyrosinase inhibitors have been …

Hyperpigmentation is a common and distressing dermatologic condition. Since tyrosinase
(TYR) plays an essential role in melanogenesis, its inhibition is considered a logical …

Stroke is considered a leading cause of mortality and neurological disability, which puts a
huge burden on individuals and the community. To date, effective therapy for stroke has …

Kojic acid, β-arbutin, α-arbutin, and deoxyarbutin have been reported as tyrosinase
inhibitors in many articles, but some contradictions exist in their differing results. In order to …

Currently, there are three major assaying methods used to validate in vitro whitening activity
from natural products: methods using mushroom tyrosinase, human tyrosinase, and …

Abstract Tyrosinases (TYRs; EC 1.14. 18.1) catalyze two sequential oxidative reactions of
the melanin biosynthesis pathway and play an important role in mammalian pigmentation …

Tyrosinases are copper-containing metalloenzymes involved in several processes in both
mammals, insects, bacteria, fungi and plants. Their phenol oxidation properties are …