The complement system is an important part of the innate immune defence. It contributes not
only to local inflammation, removal and killing of pathogens, but it also assists in shaping of …

Complement activation is associated with common rheumatic diseases such as systemic
lupus erythematosus (SLE), rheumatoid arthritis (RA) and systemic vasculitis. Evidence …

Originally discovered as part of C1, the initiation component of the classical complement
pathway, it is now appreciated that C1q regulates a variety of cellular processes …

The emergence and evolution of the complement system and mast cells (MCs) can be
traced back to sea urchins and the ascidian Styela plicata, respectively. Acting as a cascade …

Background: Tuberculosis (TB) remains a major threat to global health. Currently, diagnosis
of active TB is hampered by the lack of specific biomarkers that discriminate active TB …

Tuberculosis (TB) is a prevalent disease causing an estimated 1.6 million deaths and 10.6
million new cases annually. Discriminating TB disease from differential diagnoses can be …

The complement system is a versatile part of our immune system. Various intersection points
of complement with other cells and molecules of the immune response are well described …

Peristaltic movement of the intestine propels food down the length of the gastrointestinal
tract to promote nutrient absorption. Interactions between intestinal macrophages and the …

Multiple sclerosis (MS) is a chronic central nervous system demyelinating disease of
autoimmune originate. Complement C1q, a complex glycoprotein, mediates a variety of …

Though binding sites for the complement factor C1q and the canonical fragment
crystallizable (Fc) gamma receptors (Fc γ Rs) on immunoglobulin G (IgG) molecules overlap …