Gene of the month: GATA3

Z Qiang, I Jubber, K Lloyd, M Cumberbatch… - Journal of Clinical …, 2023 - jcp.bmj.com
GATA binding protein 3 (GATA3) is a zinc-finger pioneer transcription factor involved in
diverse processes. GATA3 regulates gene expression through binding nucleosomal DNA …

Diagnostic and Prognostic Roles of GATA3 Immunohistochemistry in Urothelial Carcinoma

D Yoo, KW Min, JS Pyo, NY Kim - Medicina, 2023 - mdpi.com
This study aimed to evaluate the diagnostic and prognostic roles of GATA-binding protein 3
(GATA3) immunohistochemistry in urothelial carcinoma (UC) using a meta-analysis. We …

Untethered microgrippers for biopsy in the upper urinary tract

W Liu, R Alam, SY Choi, Y Wan… - Advanced …, 2024 - Wiley Online Library
Untethered microrobots offer the possibility to perform medical interventions in anatomically
complex and small regions in the body. Presently, it is necessary to access the upper urinary …

[HTML][HTML] Cytokeratin 20 expression is linked to stage progression and to poor prognosis in advanced (pT4) urothelial carcinoma of the bladder

PG Bruch, H Plage, S Hofbauer, K Kornienko… - Experimental and …, 2023 - Elsevier
Abstract Cytokeratin 20 (CK20) expression is limited to umbrella cells in the normal
urothelium. Since CK20 is often upregulated in neoplastic urothelial cells including …

[HTML][HTML] TROP-2, NECTIN-4 and predictive biomarkers in sarcomatoid and rhabdoid bladder urothelial carcinoma

M Brunelli, S Gobbo, G Malpeli, G Sirgiovanni… - Pathologica, 2024 - ncbi.nlm.nih.gov
Aims In this study, we aimed to analyze TROP-2 and NECTIN-4 expression and additional
predictive biomarkers by immunohistochemistry and fluorescence in situ hybridization …

17p13 (TP53) Deletions Are Associated With an Aggressive Phenotype but Unrelated to Patient Prognosis in Urothelial Bladder Carcinomas

M Kluth, M Hitzschke, K Furlano… - Genes …, 2024 - Wiley Online Library
ABSTRACT 17p13 deletions including TP53 and other genes represent a common cause for
reduced/lost p53 function in tumor cells. In this study, we analyzed the impact of 17p13 …

PD-L1 expression in tumor and inflammatory cells is associated with favorable tumor features and favorable prognosis in muscle-invasive urothelial carcinoma of the …

H Plage, K Furlano, S Hofbauer, S Weinberger, B Ralla… - BMC urology, 2024 - Springer
Background A high level of PD-L1 expression is the most relevant predictive parameter for
response to immune checkpoint inhibitor (CPI) therapy in urinary bladder cancer. Existing …

[HTML][HTML] Absence of GATA3/FOXA1 co-expression predicts poor prognosis in upper tract urothelial carcinoma

Y Wang, Y Wang, H He, Y Xiong - Frontiers in Oncology, 2024 - frontiersin.org
Objective GATA binding protein 3 (GATA3) and forkhead box A1 (FOXA1) have been
individually implicated in the progression of upper tract urothelial carcinoma (UTUC). This …

Loss of Upk1a and Upk1b expression is linked to stage progression in urothelial carcinoma of the bladder

K Kaczmarek, H Plage, K Furlano, S Hofbauer… - … Urology and Nephrology, 2024 - Springer
Abstract Background Uroplakin-1a (Upk1a) and uroplakin-1b (Upk1b) have recently been
identified as diagnostic markers for the distinction of urothelial carcinomas from other solid …

PLAP expression is linked to invasive tumor growth in urothelial carcinoma of the bladder

H Plage, K Furlano, S Hofbauer, F Roßner… - … Urology and Nephrology, 2024 - Springer
Purpose Placental alkaline phosphatase (PLAP) is a protein with a poorly understood
function that is normally only expressed in the placenta. In cancer, PLAP expression is a …