[HTML][HTML] Cardiac transmembrane ion channels and action potentials: cellular physiology and arrhythmogenic behavior

V András, J Tomek, N Nagy, L Virág… - Physiological …, 2021 - journals.physiology.org
Cardiac arrhythmias are among the leading causes of mortality. They often arise from
alterations in the electrophysiological properties of cardiac cells and their underlying ionic …

Electrophysiology of hypokalemia and hyperkalemia

JN Weiss, Z Qu, K Shivkumar - Circulation: arrhythmia and …, 2017 - Am Heart Assoc
2 Weiss et al Potassium and Arrhythmias subthreshold EADs, thereby initiating reentry
(Figure 3, black arrows). Under these conditions, reentry can have a special property called …

Diagnosis, management and therapeutic strategies for congenital long QT syndrome

AAM Wilde, AS Amin, PG Postema - Heart, 2022 - heart.bmj.com
Congenital long QT syndrome (LQTS) is characterised by heart rate corrected QT interval
prolongation and life-threatening arrhythmias, leading to syncope and sudden death …

MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia

GW Abbott, F Sesti, I Splawski, ME Buck, MH Lehmann… - Cell, 1999 - cell.com
A novel potassium channel gene has been cloned, characterized, and associated with
cardiac arrhythmia. The gene encodes MinK-related peptide 1 (MiRP1), a small integral …

Drug-induced long QT syndrome

P Kannankeril, DM Roden, D Darbar, D Sibley - Pharmacological reviews, 2010 - Elsevier
The drug-induced long QT syndrome is a distinct clinical entity that has evolved from an
electrophysiologic curiosity to a centerpiece in drug regulation and development. This …

Cardiac ionic currents and acute ischemia: from channels to arrhythmias

E Carmeliet - Physiological reviews, 1999 - journals.physiology.org
The aim of this review is to provide basic information on the electrophysiological changes
during acute ischemia and reperfusion from the level of ion channels up to the level of …

Properties of HERG channels stably expressed in HEK 293 cells studied at physiological temperature

Z Zhou, Q Gong, B Ye, Z Fan, JC Makielski… - Biophysical journal, 1998 - cell.com
We have established stably transfected HEK 293 cell lines expressing high levels of
functional human ether-a go-go-related gene (HERG) channels. We used these cells to …

Predicting drug‐induced QT prolongation and torsades de pointes

DM Roden - The Journal of physiology, 2016 - Wiley Online Library
Drugs used to treat cardiovascular disease as well as those used in the treatment of multiple
other conditions can occasionally produce exaggerated prolongation of the QT interval on …

Differentiating drug‐induced multichannel block on the electrocardiogram: randomized study of dofetilide, quinidine, ranolazine, and verapamil

L Johannesen, J Vicente, JW Mason… - Clinical …, 2014 - Wiley Online Library
Block of the hERG potassium channel and prolongation of the QT interval are predictors of
drug‐induced torsade de pointes. However, drugs that block the hERG potassium channel …

Mechanisms, risk factors, and management of acquired long QT syndrome: a comprehensive review

EM Kallergis, CA Goudis… - The Scientific World …, 2012 - Wiley Online Library
Long QT syndrome is characterized by prolongation of the corrected QT (QTc) interval on the
surface electrocardiogram and is associated with precipitation of torsade de pointes (TdP), a …