Protein phosphorylation is the most common reversible post-translational modification in
eukaryotes. Humans have over 500 protein kinases, of which more than a dozen are …

Introduction 3. Complex and cooperative–Signal integration and deterministic signaling 3.1.
Interactions as descriptors of protein function 3.2. Cooperative binding of linear motifs 3.3 …

Protein kinases transfer a phosphoryl group from ATP onto target proteins and play a critical
role in signal transduction and other cellular processes. Here, we review the kinase kinetic …

The explosion of scientific interest in protein kinase-mediated signaling networks has led to
the infusion of new chemical methods and their applications related to the analysis of …

Quinazolines are considered as a promising class of bioactive heterocyclic compounds with
broad properties. Particularly, the quinazoline scaffold has an impressive role in the design …

The HECT E3 ligases ubiquitinate numerous transcription factors and signaling molecules,
and their activity must be tightly controlled to prevent cancer, immune disorders, and other …

Tyrosine kinases were first discovered as the protein products of viral oncogenes. We now
know that this large family of metazoan enzymes includes nearly one hundred structurally …

Tyrosine kinases and SH2 (phosphotyrosine recognition) domains have binding specificities
that depend on the amino acid sequence surrounding the target (phospho) tyrosine residue …

Bisubstrate inhibitors consist of two conjugated fragments, each targeted to a different
binding site of a bisubstrate enzyme. The design of bisubstrate inhibitors presupposes the …

The sequence of events that initiates T cell signaling is dictated by the specificities and order
of activation of the tyrosine kinases that signal downstream of the T cell receptor. Using a …