To coordinate, adapt and respond to biological signals, cells convey specific messages to
other cells. An important aspect of cell–cell communication involves secretion of molecules …

Intercellular communication is a key feature of cancer progression and metastasis.
Extracellular vesicles (EVs) are generated by all cells, including cancer cells, and recent …

Extracellular vesicles (EVs), through their complex cargo, can reflect the state of their cell of
origin and change the functions and phenotypes of other cells. These features indicate …

The lymphatic system, composed of initial and collecting lymphatic vessels as well as lymph
nodes that are present in almost every tissue of the human body, acts as an essential …

Distant metastasis is a primary cause of mortality and contributes to poor surgical outcomes
in cancer patients. Before the development of organ-specific metastasis, the formation of a …

Tumour‐draining lymph nodes (LNs) undergo massive remodelling including expansion of
the lymphatic sinuses, a process that has been linked to lymphatic metastasis by creation of …

Melanoma represents the most fatal form of skin cancer due to its resistance mechanisms
and high capacity for the development of metastases. Among other medicinal techniques …

Current research has demonstrated that extracellular vesicles (EVs) and circulating tumor
cells (CTCs) are very closely related in the process of distant tumor metastasis. Primary …

Lymphatic vessels, comprising the secondary circulatory system in human body, play a
multifaceted role in maintaining homeostasis among various tissues and organs. They are …

Extracellular vesicles (EVs) transfer bioactive molecules between cells in a process
reminiscent of enveloped viruses. EV cargo delivery is thought to occur by protein-mediated …