Appearance of pathogenic bacteria resistant to most, if not all, known antibiotics is currently
one of the most significant medical problems. Therefore, development of novel antibacterial …

The current emergence of multi-, extensively-, extremely-, and total-drug resistant strains of
Mycobacterium tuberculosis poses a major health, social, and economic threat, and stresses …

The search for new antimicrobial agents is a continuous struggle, mainly because more and
more cases of resistant strains are being reported. Mycobacterium tuberculosis (MTB) is the …

D29 mycobacteriophage encodes LysA endolysin, which mediates mycobacterial host cell
lysis by targeting its peptidoglycan layer, thus projecting itself as a potential therapeutic …

Escherichia coli O157: H7 is a foodborne pathogen that has become a serious global
concern for food safety. Despite the application of different traditional biocontrol methods in …

Endolysins produced by bacteriophages hydrolyze host cell wall peptidoglycan to release
newly assembled virions. D29 mycobacteriophage specifically infects mycobacteria …

The emergence of antibiotic-resistant and phage-resistant strains of Mycobacterium
tuberculosis (M. tuberculosis) necessitates improving new therapeutic plans. The objective …

Highlights•Phage therapy is emerging as an alternative to antibiotics.•The first case of phage
therapy in humans using engineered phages is discussed.•This was also the first case of …

Phages utilize lysis systems to allow the release of newly assembled viral particles that kill
the bacterial host. This is also the case for phage AP1, which infects the rice pathogen …

Antibiotic resistance continues to be a major global health risk with an increase in multi-drug
resistant infections seen across nearly all bacterial diseases. Mycobacterial infections such …