[HTML][HTML] Spatiotemporal insights of APP function
J Dunot, A Ribera, PA Pousinha, H Marie - Current Opinion in …, 2023 - Elsevier
The amyloid-β precursor protein (APP) is a ubiquitous protein with a strong genetic link to
Alzheimer's disease. Although the protein was identified more than forty years ago, its …
Alzheimer's disease. Although the protein was identified more than forty years ago, its …
[HTML][HTML] Probing the fluorination effect on the self-assembly characteristics, in vivo fate and antitumor efficacy of paclitaxel prodrug nanoassemblies
X Wang, B Yang, L Li, T Liu, S Zuo, D Chi, Z He… - Theranostics, 2021 - ncbi.nlm.nih.gov
Rationale: Small-molecule prodrug nanoassembly is emerging as an efficient platform for
chemotherapy. The self-assembly stability plays a vital role on the drug delivery efficiency of …
chemotherapy. The self-assembly stability plays a vital role on the drug delivery efficiency of …
Soluble amyloid-β precursor peptide does not regulate GABAB receptor activity
PD Rem, V Sereikaite, D Fernández-Fernández… - Elife, 2023 - elifesciences.org
Amyloid-β precursor protein (APP) regulates neuronal activity through the release of
secreted APP (sAPP) acting at cell surface receptors. APP and sAPP were reported to bind …
secreted APP (sAPP) acting at cell surface receptors. APP and sAPP were reported to bind …
The rigidity of a structural bridge on HLA-I binding groove explains its differential outcome in cancer immune response
The tremendous success of immune checkpoint blockade (ICB) therapy has raised the great
demand for the development of predictive biomarkers. A recent cancer genomic study …
demand for the development of predictive biomarkers. A recent cancer genomic study …
Critical roles of linker length in determining the chemical and self-assembly stability of SN38 homodimeric nanoprodrugs
X Wang, T Liu, Y Huang, F Dong, L Li, J Song… - Nanoscale …, 2023 - pubs.rsc.org
Homodimeric prodrug nanoassemblies (HDPNs) have been widely studied for efficient
cancer therapy by virtue of their ultra-high drug loading and distinct nanostructure. However …
cancer therapy by virtue of their ultra-high drug loading and distinct nanostructure. However …
Identification of the probable structure of the sAPPα-GABA B R1a complex and theoretical solutions for such cases
H Yang, J Mei, W Xu, X Ma, B Sun, H Ai - Physical Chemistry Chemical …, 2022 - pubs.rsc.org
Amyloid precursor protein (APP) is the core of the pathogenesis of Alzheimer's disease (AD).
Existing studies have shown that the soluble secreted APP (sAPPα) fragment obtained from …
Existing studies have shown that the soluble secreted APP (sAPPα) fragment obtained from …
In silico design of high-affinity antigenic peptides for HLA-B44
Cancer cell-killing by CD8+ T cells demands effective tumor antigen presentation by human
leukocyte antigen class I (HLA-I) molecules. Screening and designing highly immunogenic …
leukocyte antigen class I (HLA-I) molecules. Screening and designing highly immunogenic …
Toxicity Mechanism of Aβ42 Oligomer in the Binding between the GABABR1a sushi1 Domain and Amyloid Precursor Protein 9mer: A Mechanism like Substitution …
J Mei, H Yang, S Ahmad, X Ma, W Xu… - ACS Chemical …, 2022 - ACS Publications
Amyloid-β peptide (Aβ), characterized by its abnormal folding into neurotoxic aggregates,
impairs synaptic plasticity and causes synaptic loss associated with Alzheimer's disease …
impairs synaptic plasticity and causes synaptic loss associated with Alzheimer's disease …