[HTML][HTML] Genetics meets proteomics: perspectives for large population-based studies
Proteomic analysis of cells, tissues and body fluids has generated valuable insights into the
complex processes influencing human biology. Proteins represent intermediate phenotypes …
complex processes influencing human biology. Proteins represent intermediate phenotypes …
Recent publications from the Alzheimer's Disease Neuroimaging Initiative: Reviewing progress toward improved AD clinical trials
MW Weiner, DP Veitch, PS Aisen, LA Beckett… - Alzheimer's & …, 2017 - Elsevier
Abstract Introduction The Alzheimer's Disease Neuroimaging Initiative (ADNI) has continued
development and standardization of methodologies for biomarkers and has provided an …
development and standardization of methodologies for biomarkers and has provided an …
[HTML][HTML] Genomic atlas of the proteome from brain, CSF and plasma prioritizes proteins implicated in neurological disorders
Understanding the tissue-specific genetic controls of protein levels is essential to uncover
mechanisms of post-transcriptional gene regulation. In this study, we generated a genomic …
mechanisms of post-transcriptional gene regulation. In this study, we generated a genomic …
[HTML][HTML] Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing
Risk for late-onset Alzheimer's disease (LOAD), the most prevalent dementia, is partially
driven by genetics. To identify LOAD risk loci, we performed a large genome-wide …
driven by genetics. To identify LOAD risk loci, we performed a large genome-wide …
GWAS on family history of Alzheimer's disease
Alzheimer's disease (AD) is a public health priority for the 21st century. Risk reduction
currently revolves around lifestyle changes with much research trying to elucidate the …
currently revolves around lifestyle changes with much research trying to elucidate the …
Association of brain amyloidosis with pro-inflammatory gut bacterial taxa and peripheral inflammation markers in cognitively impaired elderly
A Cattaneo, N Cattane, S Galluzzi, S Provasi… - Neurobiology of …, 2017 - Elsevier
The pathway leading from amyloid-β deposition to cognitive impairment is believed to be a
cornerstone of the pathogenesis of Alzheimer's disease (AD). However, what drives amyloid …
cornerstone of the pathogenesis of Alzheimer's disease (AD). However, what drives amyloid …
[HTML][HTML] Proteogenomic analysis of human cerebrospinal fluid identifies neurologically relevant regulation and implicates causal proteins for Alzheimer's disease
The integration of quantitative trait loci (QTLs) with disease genome-wide association
studies (GWASs) has proven successful in prioritizing candidate genes at disease …
studies (GWASs) has proven successful in prioritizing candidate genes at disease …
[HTML][HTML] Cerebrospinal fluid soluble TREM2 is higher in Alzheimer disease and associated with mutation status
Low frequency coding variants in TREM2 are associated with increased Alzheimer disease
(AD) risk, while loss of functions mutations in the gene lead to an autosomal recessive early …
(AD) risk, while loss of functions mutations in the gene lead to an autosomal recessive early …
Clearance of cerebral Aβ in Alzheimer's disease: reassessing the role of microglia and monocytes
Deficiency in cerebral amyloid β-protein (Aβ) clearance is implicated in the pathogenesis of
the common late-onset forms of Alzheimer's disease (AD). Accumulation of misfolded Aβ in …
the common late-onset forms of Alzheimer's disease (AD). Accumulation of misfolded Aβ in …
Gut inflammation triggers C/EBPβ/δ‐secretase‐dependent gut‐to‐brain propagation of Aβ and Tau fibrils in Alzheimer's disease
Inflammation plays an important role in the pathogenesis of Alzheimer's disease (AD). Some
evidence suggests that misfolded protein aggregates found in AD brains may have …
evidence suggests that misfolded protein aggregates found in AD brains may have …