Stress is viewed as a state of real or perceived threat to homeostasis, the management of
which involves the endocrine, nervous, and immune systems. These systems work …

Humans exhibit a remarkable degree of resilience in the face of extreme stress, with most
resisting the development of neuropsychiatric disorders. Over the past 5 years, there has …

BACKGROUND: Adult-onset stressors exert opposing effects on hippocampal neurogenesis
and cognition, with enhancement observed following mild stress and dysfunction following …

Viable new treatments for depression and anxiety have been slow to emerge, likely owing to
the complex and incompletely understood etiology of these disorders. A budding area of …

Chronic stress is one of the predominant environmental risk factors for a number of
psychiatric disorders, particularly for major depression. Different hypotheses have been …

Understanding the neurobiological mechanisms of post-traumatic stress disorder (PTSD) is
of vital importance for developing biomarkers and more effective pharmacotherapy for this …

The development of a persistent depressive affective state has for some time been thought
to result from persistent alterations in neurotransmitter-mediated synaptic transmission …

Stress in adolescence has been widely demonstrated to have a lasting impact in humans
and animal models. Developmental risk and protective factors play an important role in the …

Stress is a major risk factor for neurodevelopmental and neuropsychiatric disorders, with the
capacity to impact susceptibility to disease as well as long-term neurobiological and …

We review the still scarce but growing literature on resilience to the effects of social stress on
the rewarding properties of drugs of abuse. We define the concept of resilience and how it is …