Repair of double-strand breaks by end joining
KK Chiruvella, Z Liang… - Cold Spring Harbor …, 2013 - cshperspectives.cshlp.org
Nonhomologous end joining (NHEJ) refers to a set of genome maintenance pathways in
which two DNA double-strand break (DSB) ends are (re) joined by apposition, processing …
which two DNA double-strand break (DSB) ends are (re) joined by apposition, processing …
[HTML][HTML] Mechanisms of programmed DNA lesions and genomic instability in the immune system
Chromosomal translocations involving antigen receptor loci are common in lymphoid
malignancies. Translocations require DNA double-strand breaks (DSBs) at two …
malignancies. Translocations require DNA double-strand breaks (DSBs) at two …
[HTML][HTML] A cell cycle-dependent regulatory circuit composed of 53BP1-RIF1 and BRCA1-CtIP controls DNA repair pathway choice
C Escribano-Díaz, A Orthwein, A Fradet-Turcotte… - Molecular cell, 2013 - cell.com
DNA double-strand break (DSB) repair pathway choice is governed by the opposing
activities of 53BP1 and BRCA1. 53BP1 stimulates nonhomologous end joining (NHEJ) …
activities of 53BP1 and BRCA1. 53BP1 stimulates nonhomologous end joining (NHEJ) …
Modernizing the nonhomologous end-joining repertoire: alternative and classical NHEJ share the stage
L Deriano, DB Roth - Annual review of genetics, 2013 - annualreviews.org
DNA double-strand breaks (DSBs) are common lesions that continually threaten genomic
integrity. Failure to repair a DSB has deleterious consequences, including cell death …
integrity. Failure to repair a DSB has deleterious consequences, including cell death …
Function and molecular mechanism of the DNA damage response in immunity and cancer immunotherapy
The DNA damage response (DDR) is an organized network of multiple interwoven
components evolved to repair damaged DNA and maintain genome fidelity. Conceptually …
components evolved to repair damaged DNA and maintain genome fidelity. Conceptually …
Classical and alternative end-joining pathways for repair of lymphocyte-specific and general DNA double-strand breaks
Classical nonhomologous end joining (C-NHEJ) is one of the two major known pathways for
the repair of DNA double-strand breaks (DSBs) in mammalian cells. Our understanding of C …
the repair of DNA double-strand breaks (DSBs) in mammalian cells. Our understanding of C …
[HTML][HTML] Alternative end-joining pathway (s): bricolage at DNA breaks
P Frit, N Barboule, Y Yuan, D Gomez, P Calsou - DNA repair, 2014 - Elsevier
To cope with DNA double strand break (DSB) genotoxicity, cells have evolved two main
repair pathways: homologous recombination which uses homologous DNA sequences as …
repair pathways: homologous recombination which uses homologous DNA sequences as …
Role of 53BP1 in the regulation of DNA double-strand break repair pathway choice
A Gupta, CR Hunt, S Chakraborty… - Radiation …, 2014 - meridian.allenpress.com
The p53-binding protein 1 (53BP1) is a well-known DNA damage response (DDR) factor,
which is recruited to nuclear structures at the site of DNA damage and forms readily …
which is recruited to nuclear structures at the site of DNA damage and forms readily …
MRI is a DNA damage response adaptor during classical non-homologous end joining
PJ Hung, B Johnson, BR Chen, AK Byrum… - Molecular cell, 2018 - cell.com
The modulator of retrovirus infection (MRI or CYREN) is a 30-kDa protein with a conserved
N-terminal Ku-binding motif (KBM) and a C-terminal XLF-like motif (XLM). We show that MRI …
N-terminal Ku-binding motif (KBM) and a C-terminal XLF-like motif (XLM). We show that MRI …
PAXX promotes KU accumulation at DNA breaks and is essential for end-joining in XLF-deficient mice
Non-homologous end-joining (NHEJ) is the most prominent DNA double strand break (DSB)
repair pathway in mammalian cells. PAXX is the newest NHEJ factor, which shares structural …
repair pathway in mammalian cells. PAXX is the newest NHEJ factor, which shares structural …