Schizosaccharomyces pombe (fission yeast) is an attractive model for mitochondrial
research. The organism resembles human cells in terms of mitochondrial inheritance …

In human cells, the nuclear and mitochondrial genomes engage in a complex interplay to
produce dual-encoded oxidative phosphorylation (OXPHOS) complexes. The coordination …

Transcription initiation is a key regulatory step in gene expression during which RNA
polymerase (RNAP) initiates RNA synthesis de novo, and the synthesized RNA at a specific …

Replication of the mitochondrial genome and expression of the genes it encodes both
depend on a sufficient supply of nucleotides to mitochondria. Accordingly, dysregulated …

High oxidative phosphorylation (OXPHOS) happens in some tumors, which depends on
OXPHOS for energy supply, particularly in slow-cycling tumor cells. Therefore, targeting …

Ageing is an inevitable phenomenon which affects the cellular to the organism level in the
progression of the time. Oxidative stress and inflammation are now widely regarded as the …

Complexome profiling (CP) is a powerful tool for systematic investigation of protein
interactors that has been primarily applied to study the composition and dynamics of …

Pathogen-specific rewiring of host cell metabolism creates the metabolically adapted
microenvironment required for pathogen replication. Here, we investigated the mechanisms …

Mitochondria are vital organelles present in almost all eukaryotic cells. Although most of the
mitochondrial proteins are nuclear-encoded, mitochondria contain their own genome …

Mitochondria are major organelles involved in several processes related to energy supply,
metabolism, and cell proliferation. The mitochondria function is transcriptionally regulated by …