BACKGROUND: Traumatic spinal cord injuries (SCI) have devastating consequences for the
physical, financial, and psychosocial well-being of patients and their caregivers. Expediently …

DNA methylation has a profound impact on genome stability, transcription and development.
Although enzymes that catalyse DNA methylation have been well characterized, those that …

Methylation of cytosines in the mammalian genome represents a key epigenetic modification
and is dynamically regulated during development. Compelling evidence now suggests that …

DNA demethylation can occur passively by “dilution” of methylation marks by DNA
replication, or actively and independently of DNA replication. Direct conversion of 5 …

Diffuse large B-cell lymphoma (DLBCL) is the most common type of lymphoma and is
notorious for its heterogeneity, aggressive nature, and the frequent development of …

Chronic inflammation is a prerequisite for the development of cancers. Here, we present the
framework of a novel theory termed as Cancer Evolution-Development (Cancer Evo-Dev) …

Upon encountering antigens, mature IgM-positive B lymphocytes undergo class-switch
recombination (CSR) wherein exons encoding the default Cμ constant coding gene …

The AID/APOBEC family enzymes convert cytosines in single-stranded DNA to uracils,
causing base substitutions and strand breaks. They are induced by cytokines produced …

Despite advances in the field of somatic cell reprogramming, an understanding and
exploration of the underlying mechanisms governing this process are only recently …

Deciphering the mechanisms of epigenetic reprogramming provides fundamental insights
into cell fate decisions, which in turn reveal strategies to make the reprogramming process …