Transplanting marginal organs in the era of modern machine perfusion and advanced organ monitoring

T Resch, B Cardini, R Oberhuber… - Frontiers in …, 2020 - frontiersin.org
Organ transplantation is undergoing profound changes. Contraindications for donation have
been revised in order to better meet the organ demand. The use of lower-quality organs and …

Expanding controlled donation after the circulatory determination of death: statement from an international collaborative

B Domínguez-Gil, N Ascher, AM Capron… - Intensive care …, 2021 - Springer
A decision to withdraw life-sustaining treatment (WLST) is derived by a conclusion that
further treatment will not enable a patient to survive or will not produce a functional outcome …

A focused review on primary graft dysfunction after clinical lung transplantation: A multilevel syndrome

J Van Slambrouck, D Van Raemdonck, R Vos… - Cells, 2022 - mdpi.com
Primary graft dysfunction (PGD) is the clinical syndrome of acute lung injury after lung
transplantation (LTx). However, PGD is an umbrella term that encompasses the ongoing …

A nonrandomized open-label phase 2 trial of nonischemic heart preservation for human heart transplantation

J Nilsson, V Jernryd, G Qin, A Paskevicius… - Nature …, 2020 - nature.com
Pre-clinical heart transplantation studies have shown that ex vivo non-ischemic heart
preservation (NIHP) can be safely used for 24 h. Here we perform a prospective, open-label …

Portable normothermic ex-vivo lung perfusion, ventilation, and functional assessment with the Organ Care System on donor lung use for transplantation from extended …

G Loor, G Warnecke, MA Villavicencio… - The Lancet …, 2019 - thelancet.com
Background Donor lung use for transplantation is the lowest among solid organ tranplants
because of several complex and multifactorial reasons; one area that could have a …

Genetic Engineering of the Kidney to Permanently Silence MHC Transcripts During ex vivo Organ Perfusion

Y Yuzefovych, E Valdivia, S Rong, F Hack… - Frontiers in …, 2020 - frontiersin.org
Organ gene therapy represents a promising tool to correct diseases or improve graft survival
after transplantation. Polymorphic variation of the major histocompatibility complex (MHC) …

Ex-vivo preservation with the organ care system in high risk heart transplantation

SV Rojas, M Avsar, F Ius, D Schibilsky, T Kaufeld… - Life, 2022 - mdpi.com
Objective: Ex vivo organ perfusion is an advanced preservation technique that allows graft
assessment and extended ex situ intervals. We hypothesized that its properties might be …

[HTML][HTML] The donor heart and organ perfusion technology

HC Chew, PS Macdonald, KK Dhital - Journal of thoracic disease, 2019 - ncbi.nlm.nih.gov
Recent advancement in organ perfusion technology has led to increase clinical
transplantation of marginal donor organs and allow for distant procurement of cardiac …

[HTML][HTML] Ex vivo lung perfusion prior to transplantation: an overview of current clinical practice worldwide

J Possoz, A Neyrinck… - Journal of Thoracic …, 2019 - ncbi.nlm.nih.gov
Lung transplantation is a lifesaving treatment in numerous forms of end-stage lung disease
but organ shortage remains nowadays his biggest issue. Ex vivo lung perfusion (EVLP) has …

Lung donation after circulatory death

LJ Ceulemans, I Inci… - Current opinion in organ …, 2019 - journals.lww.com
Lung donation after circulatory death : Current Opinion in Organ Transplantation Lung donation
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