[HTML][HTML] Sex hormone binding globulin as a potential drug candidate for liver-related metabolic disorders treatment

N Bourebaba, TH Ngo, A Śmieszek… - Biomedicine & …, 2022 - Elsevier
Sex hormone binding globulin (SHBG) is a hepatokine that binds to circulating steroid
hormones (testosterone, oestradiol) to regulate their concentration in the bloodstream …

Fructose 1-phosphate, an evolutionary signaling molecule of abundancy

MCGJ Brouwers - Trends in Endocrinology & Metabolism, 2022 - cell.com
Evidence is accumulating that specifically fructose exerts adverse cardiometabolic effects in
humans. Recent experimental studies have shown that fructose not only serves as a …

Serum sex hormone-binding globulin is a mediator of the association between intrahepatic lipid content and type 2 diabetes: the Maastricht Study

PIHG Simons, O Valkenburg, MPH van de Waarenburg… - Diabetologia, 2023 - Springer
Aims/hypothesis Serum sex hormone-binding globulin (SHBG) has been proposed to act as
a hepatokine that contributes to the extrahepatic complications observed in non-alcoholic …

Sex hormone-binding globulin improves lipid metabolism and reduces inflammation in subcutaneous adipose tissue of metabolic syndrome-affected horses

L Bourebaba, M Kępska, B Qasem, M Zyzak… - Frontiers in molecular …, 2023 - frontiersin.org
Equine metabolic syndrome (EMS) is a steadily growing endocrine disorder representing a
real challenge in veterinary practice. As a multifactorial condition, EMS is characterized by …

Alternative dosing regimen of exemestane in a randomized presurgical trial: the role of obesity in biomarker modulation

H Johansson, A Guerrieri-Gonzaga, S Gandini… - NPJ Breast …, 2024 - nature.com
In a 3-arm presurgical trial, four-six weeks exemestane 25 mg three times/week (TIW) was
non-inferior to 25 mg/day (QD) in suppressing circulating estradiol in postmenopausal …

Association Between Low Sex Hormone–Binding Globulin and Increased Risk of Type 2 Diabetes Is Mediated by Increased Visceral and Liver Fat: Results From …

TA Stangl, CM Wiepjes, RAJ Smit… - Diabetes, 2024 - diabetesjournals.org
The aim of this study was to investigate the associations among sex hormone–binding
globulin (SHBG), visceral adipose tissue (VAT), liver fat content, and risk of type 2 diabetes …

The relationships of sex hormone‐binding globulin, total testosterone, androstenedione and free testosterone with metabolic and reproductive features of polycystic …

PIHG Simons, O Valkenburg, JAP Bons… - Endocrinology …, 2021 - Wiley Online Library
Objective A recent Mendelian randomization study has suggested a causal role for sex
hormone‐binding globulin (SHBG), total testosterone and free testosterone in the …

Sex hormone-binding globulin (SHBG) reduction: the alarm bell for the risk of non-alcoholic fatty liver disease in adolescents with polycystic ovary syndrome

F Urbano, M Chiarito, C Lattanzio, A Messa, M Ferrante… - Children, 2022 - mdpi.com
Polycystic ovary syndrome (PCOS) represents an endocrine condition affecting 5–18% of
adolescents, frequently in association with obesity, metabolic alterations, and liver …

[HTML][HTML] Association between de novo lipogenesis susceptibility genes and coronary artery disease

PIHG Simons, O Valkenburg, CDA Stehouwer… - Nutrition, Metabolism …, 2022 - Elsevier
Background and aims Coronary artery disease (CAD) is the principal cause of death in
individuals with non-alcoholic fatty liver disease (NAFLD). The aim of this study was to use …

Sex hormone binding globulin (SHBG) modulates mitochondrial dynamics in PPARγ-depleted equine adipose derived stromal cells

K Marycz, B Wiatrak, JM Irwin-Houston… - Journal of Molecular …, 2024 - Springer
Peroxisome proliferator-activated receptor gamma (PPARγ) is a transcription factor that
promotes adipogenesis, lipid uptake and storage, insulin sensitivity, and glucose …