A review of inflammatory mechanism in airway diseases
P Aghasafari, U George, R Pidaparti - Inflammation Research, 2019 - Springer
Background Inflammation in the lung is the body's natural response to injury. It acts to
remove harmful stimuli such as pathogens, irritants, and damaged cells and initiate the …
remove harmful stimuli such as pathogens, irritants, and damaged cells and initiate the …
Sepsis: multiple abnormalities, heterogeneous responses, and evolving understanding
KN Iskander, MF Osuchowski… - Physiological …, 2013 - journals.physiology.org
Sepsis represents the host's systemic inflammatory response to a severe infection. It causes
substantial human morbidity resulting in hundreds of thousands of deaths each year …
substantial human morbidity resulting in hundreds of thousands of deaths each year …
Translational systems biology of inflammation
Y Vodovotz, M Csete, J Bartels… - PLoS computational …, 2008 - journals.plos.org
Inflammation is a complex, multi-scale biologic response to stress that is also required for
repair and regeneration after injury. Despite the repository of detailed data about the cellular …
repair and regeneration after injury. Despite the repository of detailed data about the cellular …
Modeling and simulations of CoViD-19 molecular mechanism induced by cytokines storm during SARS-CoV2 infection
It is highly desired to explore the interventions of COVID-19 for early treatment strategies.
Such interventions are still under consideration. A model is benchmarked research and …
Such interventions are still under consideration. A model is benchmarked research and …
Sepsis: Something old, something new, and a systems view
Sepsis is a clinical syndrome characterized by a multisystem response to a microbial
pathogenic insult consisting of a mosaic of interconnected biochemical, cellular, and organ …
pathogenic insult consisting of a mosaic of interconnected biochemical, cellular, and organ …
A reduced mathematical model of the acute inflammatory response II. Capturing scenarios of repeated endotoxin administration
Bacterial lipopolysaccharide (LPS; endotoxin) is a potent immunostimulant that can induce
an acute inflammatory response comparable to a bacterial infection. Experimental …
an acute inflammatory response comparable to a bacterial infection. Experimental …
Mathematical model of a three-stage innate immune response to a pneumococcal lung infection
Pneumococcal pneumonia is a leading cause of death and a major source of human
morbidity. The initial immune response plays a central role in determining the course and …
morbidity. The initial immune response plays a central role in determining the course and …
Mechanistic simulations of inflammation: current state and future prospects
Inflammation is a normal, robust physiological process. It can also be viewed as a complex
system that senses and attempts to resolve homeostatic perturbations initiated from within …
system that senses and attempts to resolve homeostatic perturbations initiated from within …
Modeling oncolytic viral therapy, immune checkpoint inhibition, and the complex dynamics of innate and adaptive immunity in glioblastoma treatment
KM Storey, SE Lawler, TL Jackson - Frontiers in physiology, 2020 - frontiersin.org
Oncolytic viruses are of growing interest to cancer researchers and clinicians, due to their
selectivity for tumor cells over healthy cells and their immunostimulatory properties. The …
selectivity for tumor cells over healthy cells and their immunostimulatory properties. The …
The acute inflammatory response in trauma/hemorrhage and traumatic brain injury: current state and emerging prospects
Traumatic injury/hemorrhagic shock (T/HS) elicits an acute inflammatory response that may
result in death. Inflammation describes a coordinated series of molecular, cellular, tissue …
result in death. Inflammation describes a coordinated series of molecular, cellular, tissue …