Hydrazide-hydrazone/hydrazone as enabling linkers in anti-cancer drug discovery: A comprehensive review
S Murugappan, S Dastari, K Jungare, NM Barve… - Journal of Molecular …, 2024 - Elsevier
The burgeoning demand for novel cytotoxic drugs possessing improved bioavailability and
safety profiles has spurred the hybridization of various pharmacophores in the past decades …
safety profiles has spurred the hybridization of various pharmacophores in the past decades …
Naproxen based 1, 3, 4-oxadiazole derivatives as EGFR inhibitors: Design, synthesis, anticancer, and computational studies
MM Alam, S Nazreen, ASA Almalki, AA Elhenawy… - Pharmaceuticals, 2021 - mdpi.com
A library of novel naproxen based 1, 3, 4-oxadiazole derivatives (8–16 and 19–26) has been
synthesized and screened for cytotoxicity as EGFR inhibitors. Among the synthesized …
synthesized and screened for cytotoxicity as EGFR inhibitors. Among the synthesized …
Biooriented Synthesis of Ibuprofen-Clubbed Novel Bis-Schiff Base Derivatives as Potential Hits for Malignant Glioma: In Vitro Anticancer Activity and In Silico …
This research work is based on the synthesis of bis-Schiff base derivatives of the
commercially available ibuprofen drug in outstanding yields through multistep reactions …
commercially available ibuprofen drug in outstanding yields through multistep reactions …
Synthesis and anticancer activity of novel hydrazone linkage-based aryl sulfonate derivatives as apoptosis inducers
In the present study, the various 28 hybrid molecules containing hydrazone and sulfonate
moieties were synthesized and characterized by FTIR, 1H-NMR, 13C-NMR spectroscopy …
moieties were synthesized and characterized by FTIR, 1H-NMR, 13C-NMR spectroscopy …
Repurposing of Indomethacin and Naproxen as anticancer agents: progress from 2017 to present
Inflammation is strongly linked to cancer and is essential for the growth and development of
tumors. Targeting inflammation and the mediators involved in the inflammatory process …
tumors. Targeting inflammation and the mediators involved in the inflammatory process …
Design, synthesis, and anticancer evaluation of novel tetracaine hydrazide-hydrazones
Mİ Han, N Imamoglu - ACS omega, 2023 - ACS Publications
Tetracaine is an ester derivative used as a local anesthetic molecule. In this study, a series
of novel Tetracaine derivatives bearing hydrazide-hydrazone moiety were designed …
of novel Tetracaine derivatives bearing hydrazide-hydrazone moiety were designed …
Design, synthesis, molecular modeling, and anticancer evaluation of new VEGFR-2 inhibitors based on the indolin-2-One scaffold
A new series of indoline-2-one derivatives was designed and synthesized based on the
essential pharmacophoric features of VEGFR-2 inhibitors. Anti-proliferative activities were …
essential pharmacophoric features of VEGFR-2 inhibitors. Anti-proliferative activities were …
Design, synthesis and anticancer activity studies of novel 4-butylaminophenyl hydrazide-hydrazones as apoptotic inducers
In this study, a series of the novel Tetracaine derivatives bearing hydrazide-hydrazone
moiety were designed, synthesized, and evaluated for anticancer activity. The structures of …
moiety were designed, synthesized, and evaluated for anticancer activity. The structures of …
Synthesis of new pyrazolidines by [3+ 2] cycloaddition: Anticancer, antioxidant activities, and molecular docking studies
A series of novel pyrazolidine derivatives 2a-j from N-acyl hydrazones 1a-j were designed
and synthesized by N-triflylphosphoramide (NTPA) catalyzed [3+ 2] cycloaddition. The …
and synthesized by N-triflylphosphoramide (NTPA) catalyzed [3+ 2] cycloaddition. The …
Design, Synthesis, and In Vitro and In Vivo Bioactivity Studies of Hydrazide–Hydrazones of 2, 4-Dihydroxybenzoic Acid
Ł Popiołek, M Gawrońska-Grzywacz, A Dziduch… - International Journal of …, 2023 - mdpi.com
In this research, twenty-four hydrazide–hydrazones of 2, 4-dihydroxybenzoic acid were
designed, synthesized, and subjected to in vitro and in vivo bioactivity studies. The chemical …
designed, synthesized, and subjected to in vitro and in vivo bioactivity studies. The chemical …