Heart failure and related morbidity and mortality are increasing at an alarming rate, in large
part, because of increases in aging, obesity, and diabetes mellitus. The clinical outcomes …

The endoplasmic reticulum (ER) is a morphologically and functionally diverse organelle
capable of integrating multiple extracellular and internal signals and generating adaptive …

Níveis de evidência Nível A Dados obtidos a partir de múltiplos estudos randomizados de
bom porte, concordantes e/ou de meta-análise robusta de estudos clínicos randomizados …

Level of evidence Level A Data obtained from multiple concordant large randomized trials
and/or robust meta-analysis of randomized clinical trials Level B Data obtained from less …

Diabetic cardiomyopathy (DCM) is a diabetes mellitus–induced pathophysiological
condition characterized by cardiac structural, functional, and metabolic changes that can …

Phospholamban (PLN) is a phosphoprotein in cardiac sarcoplasmic reticulum (SR) that is a
reversible regulator of the Ca2+-ATPase (SERCA2a) activity and cardiac contractility …

Obese pregnancies are not only associated with adverse consequences for the mother but
also the long-term health of her child. Human studies have shown that individuals from …

Calcium dynamics is central in cardiac physiology, as the key event leading to the excitation-
contraction coupling (ECC) and relaxation processes. The primary function of Ca2+ in the …

Cachexia is a common syndrome in advanced cancer patients and causes up to 22% of
cancer-related deaths. It remains elusive whether cancer cachexia causes heart failure. We …

Stress hyperglycemia is a transient increase in blood glucose during acute physiological
stress in the absence of glucose homeostasis dysfunction. Its's presence has been …