Simple Summary The human pathogen Pseudomonas aeruginosa (P. aeruginosa) causes
several infections, both acute and chronic, mainly in hosts with compromised immunity and …

Metal cations are indispensable components of the cellular machinery and are involved in
numerous essential tasks ranging from nucleic acid and protein structure stabilization to …

All organisms must regulate the cellular uptake, efflux, and intracellular trafficking of
essential elements, including d-block metal ions. In bacteria, such regulation is achieved by …

Metalloregulatory proteins allow cells to sense metal ions and appropriately adjust the
expression of metal uptake, storage, and efflux pathways. Bacillus subtilis provides a model …

Bacterial transition metal homoeostasis or simply 'metallostasis' describes the process by
which cells control the intracellular availability of functionally required metal cofactors, from …

Cadmium is a transition metal ion that is highly toxic in biological systems. Although
relatively rare in the Earth's crust, anthropogenic release of cadmium since industrialization …

Highlights•The 'fight over copper and zinc'at the host–pathogen interface is
discussed.•Proteins involved in copper and zinc trafficking and sensing are …

Commensal microbes, whether they are beneficial or pathogenic, are sensitive to host
processes that starve or swamp the prokaryote with large fluctuations in local zinc …

Between 5 and 10% of all proteins of a given organism are estimated to require zinc for
function, and hence zinc is essential for almost any given metabolic process. It is therefore of …

IscR from Escherichia coli is an unusual metalloregulator in that both apo and iron sulfur (Fe-
S)-IscR regulate transcription and exhibit different DNA binding specificities. Here, we report …