Ligand‐Directed Divergent Synthesis of Carbo‐and Heterocyclic Ring Systems

YC Lee, K Kumar, H Waldmann - … Chemie International Edition, 2018 - Wiley Online Library
Chemical tools that enable a catalytic reaction to selectively and efficiently yield different
products will allow charting of wider chemical space. In ligand‐directed divergent synthesis …

Post-Ugi cyclization for the construction of diverse heterocyclic compounds: recent updates

J Bariwal, R Kaur, LG Voskressensky… - Frontiers in …, 2018 - frontiersin.org
Multicomponent reactions (MCRs) have proved as a valuable tool for organic and medicinal
chemist because of their ability to introduce a large degree of chemical diversity in the …

A Gold‐Catalyzed Domino Cyclization Enabling Rapid Construction of Diverse Polyheterocyclic Frameworks

Y He, Z Li, K Robeyns, L Van Meervelt… - Angewandte Chemie …, 2018 - Wiley Online Library
We report herein an efficient gold (I)‐catalyzed post‐Ugi domino dearomatization/ipso‐
cyclization/Michael sequence that enables access to libraries of diverse (hetero) arene …

Post‐Ugi Cyclizations Towards Polycyclic N‐Heterocycles

X Tang, L Song, EV Van der Eycken - The Chemical Record, 2023 - Wiley Online Library
The Ugi reaction has become one of the highly explored reactions for the formation of
multifunctional adducts, due to the mild reaction conditions, wide scope and high variability …

Gold-catalyzed diastereoselective domino dearomatization/ipso-cyclization/aza-Michael sequence: a facile access to diverse fused azaspiro tetracyclic scaffolds

Y He, Z Li, G Tian, L Song, L Van Meervelt… - Chemical …, 2017 - pubs.rsc.org
A facile and diversity-oriented access to complex tetracyclic benzo [e] pyrrolo [2, 3-c] indole-
2, 4, 7 (5H)-triones through a post-Ugi gold (I)-catalyzed domino dearomatization/ipso …

Asymmetric synthesis of tetrahydroisoquinoline-fused spirooxindoles as Ras-GTP inhibitors that inhibit colon adenocarcinoma cell proliferation and invasion

Q Zhao, C Peng, H Huang, SJ Liu, YJ Zhong… - Chemical …, 2018 - pubs.rsc.org
Here we report the synthesis of a library of chiral THIQ-fused spirooxindoles, which combine
two privileged scaffolds in antitumor medicinal chemistry. Some of the library members …

Access to Polycyclic Azepino[5,4,3-cd]indoles via a Gold-Catalyzed Post-Ugi Dearomatization Cascade

Y He, L Song, C Liu, D Wu, Z Li… - The Journal of …, 2020 - ACS Publications
The development of a rapid and diverse access to complex natural product-like 3, 4-fused
indole scaffolds has always attracted considerable attention from synthetic and medicinal …

Modular access to diverse bridged indole alkaloid mimics via a gold-triggered cascade dearomative spirocarbocyclization/[4+ 2] cycloaddition sequence

Y He, Z Liu, D Wu, Z Li, K Robeyns… - Organic …, 2019 - ACS Publications
A modular and streamlined synthetic strategy for the generation of bridged indole alkaloid-
like heterocycles from easily available building blocks is elaborated. This approach utilizes …

Dieckmann Condensation of Ugi N-Acylamino Amide Product: Facile Access to Functionalized 2,2-Disubstituted Indolin-3-ones

Y Li, J Xu, LJ He, YF Luo, JP Meng… - The Journal of …, 2021 - ACS Publications
Structurally unique 2, 2-disubstituted indolin-3-ones with a quaternary carbon center have
been constructed through a novel C–C bond formation at the C3 position of Ugi N-acylamino …

Removal of copper ions by functionalized biochar based on a multicomponent Ugi reaction

Q Liu, GL Zang, Q Zhao - RSC advances, 2021 - pubs.rsc.org
Copper is widely present in the natural environment and inevitably poses a risk to both
human health and the natural environment. Biochar is an inexpensive, clean and …