Mechanisms of oocyte aneuploidy associated with advanced maternal age
It is well established that maternal age is associated with a rapid decline in the production of
healthy and high-quality oocytes resulting in reduced fertility in women older than 35 years …
healthy and high-quality oocytes resulting in reduced fertility in women older than 35 years …
Human female meiosis revised: new insights into the mechanisms of chromosome segregation and aneuploidies from advanced genomics and time-lapse imaging
A Capalbo, ER Hoffmann, D Cimadomo… - Human reproduction …, 2017 - academic.oup.com
ABSTRACT BACKGROUND The unbalanced transmission of chromosomes in human
gametes and early preimplantation embryos causes aneuploidy, which is a major cause of …
gametes and early preimplantation embryos causes aneuploidy, which is a major cause of …
Meiosis interrupted: the genetics of female infertility via meiotic failure
Idiopathic or “unexplained” infertility represents as many as 30% of infertility cases
worldwide. Conception, implantation, and term delivery of developmentally healthy infants …
worldwide. Conception, implantation, and term delivery of developmentally healthy infants …
Preconception genome medicine: current state and future perspectives to improve infertility diagnosis and reproductive and health outcomes based on individual …
A Capalbo, M Poli, A Riera-Escamilla… - Human reproduction …, 2021 - academic.oup.com
BACKGROUND Our genetic code is now readable, writable and hackable. The recent
escalation of genome-wide sequencing (GS) applications in population diagnostics will not …
escalation of genome-wide sequencing (GS) applications in population diagnostics will not …
Origins and mechanisms leading to aneuploidy in human eggs
L Wartosch, K Schindler, M Schuh, JR Gruhn… - Prenatal …, 2021 - Wiley Online Library
The gain or loss of a chromosome—or aneuploidy—acts as one of the major triggers for
infertility and pregnancy loss in humans. These chromosomal abnormalities affect more than …
infertility and pregnancy loss in humans. These chromosomal abnormalities affect more than …
Regulation of chromosome segregation in oocytes and the cellular basis for female meiotic errors
BACKGROUND Meiotic chromosome segregation in human oocytes is notoriously error-
prone, especially with ageing. Such errors markedly reduce the reproductive chances of …
prone, especially with ageing. Such errors markedly reduce the reproductive chances of …
Errors of the egg: the establishment and progression of human aneuploidy research in the maternal germline
JR Gruhn, ER Hoffmann - Annual review of genetics, 2022 - annualreviews.org
Meiosis, a key process in the creation of haploid gametes, is a complex cellular division
incorporating unique timing and intricate chromosome dynamics. Abnormalities in this …
incorporating unique timing and intricate chromosome dynamics. Abnormalities in this …
Aneuploidy in human eggs: contributions of the meiotic spindle
Human eggs frequently contain an incorrect number of chromosomes, a condition termed
aneuploidy. Aneuploidy affects∼ 10–25% of eggs in women in their early 30s, and more …
aneuploidy. Aneuploidy affects∼ 10–25% of eggs in women in their early 30s, and more …
Age‐dependent integrity of the meiotic spindle assembly checkpoint in females requires Aurora kinase B
A hallmark of advanced maternal age is a significant increase in meiotic chromosome
segregation errors, resulting in early miscarriages and congenital disorders. These errors …
segregation errors, resulting in early miscarriages and congenital disorders. These errors …
Causes and consequences of chromosome segregation error in preimplantation embryos
C Vázquez-Diez, G FitzHarris - Reproduction, 2018 - rep.bioscientifica.com
Errors in chromosome segregation are common during the mitotic divisions of
preimplantation development in mammalian embryos, giving rise to so-called …
preimplantation development in mammalian embryos, giving rise to so-called …