Tumor-targeting peptides: ligands for molecular imaging and therapy

N Zhao, Y Qin, H Liu, Z Cheng - Anti-Cancer Agents in …, 2018 - ingentaconnect.com
The aberrant proliferation of tumor cells and abundant vasculature in tumor tissues are
closely correlated with receptors that are specifically dysregulated in tumor cells. These …

[HTML][HTML] Advances in the regulatory effects of bioactive peptides on metabolic signaling pathways in tumor cells

H Cui, W Han, J Zhang, Z Zhang, X Su - Journal of Cancer, 2019 - ncbi.nlm.nih.gov
Abstract Changes in cell metabolism are an important feature of tumors that has always
been an intense topic of study, particularly in regard to whether metabolic disorders are a …

Peptides and pseudopeptide ligands: a powerful toolbox for the affinity purification of current and next-generation biotherapeutics

W Chu, R Prodromou, KN Day, JD Schneible… - … of Chromatography A, 2021 - Elsevier
Following the consolidation of therapeutic proteins in the fight against cancer, autoimmune,
and neurodegenerative diseases, recent advancements in biochemistry and biotechnology …

De-immunized, shiga toxin a subunit scaffolds and cell-targeting molecules comprising the same

P Eric, E Willert, GL Robinson, S Rajagopalan… - 2020 - Google Patents
CXQCLLQQYTUUKJ-ALWAHNIESA-N (2S, 4S, 5R, 6R)-5-acetamido-6-[(1S, 2R)-2-[(2S, 4S,
5R, 6R)-5-acetamido-2-carboxy-4-hydroxy-6-[(1R, 2R)-1, 2, 3-trihydroxypropyl] oxan-2-yl] …

Assessing biofilm inhibition and immunomodulatory activity of small amounts of synthetic host defense peptides synthesized using SPOT-array technology

H Etayash, EF Haney, REW Hancock - Nature Protocols, 2021 - nature.com
Peptides are promising drug candidates because of their diversity, biocompatibility and
spectrum of activities. Here, we describe a protocol for high-throughput screening of SPOT …

The Improved Delivery to Breast Cancer Based on a Novel Nanocarrier Modified with High‐Affinity Peptides Discovered by Phage Display

H Zhang, Z Guo, B He, W Dai, H Zhang… - Advanced …, 2018 - Wiley Online Library
Ligand‐targeted nanosystems have the potential to realize site‐specific tumor therapy and
alleviate unwanted side effects of many chemotherapeutic agents, and one of the most key …

Proteins comprising binding regions, shiga toxin a subunit effector regions, and carboxy-terminal, endoplasmic reticulum localization signal motifs

P Eric, E WILLERT, J Kim, J Higgins - 2020 - Google Patents
YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl) anilino] pyrimidin-4-yl]
amino] phenyl] cyclopropanecarboxamide Chemical compound FC (F)(F) C1= CC= CC …

Cell-targeting molecules comprising de-immunized, shiga toxin a subunit effectors and cd8+ t-cell epitopes

P Eric, E WILLERT, S Rajagopalan, GL ROBINSON… - 2018 - Google Patents
CXQCLLQQYTUUKJ-ALWAHNIESA-N (2S, 4S, 5R, 6R)-5-acetamido-6-[(1S, 2R)-2-[(2S, 4S,
5R, 6R)-5-acetamido-2-carboxy-4-hydroxy-6-[(1R, 2R)-1, 2, 3-trihydroxypropyl] oxan-2-yl] …

De-immunized, shiga toxin a subunit scaffolds and cell-targeting molecules comprising the same

P Eric, E WILLERT, GL ROBINSON, S Rajagopalan… - 2016 - Google Patents
CXQCLLQQYTUUKJ-ALWAHNIESA-N (2S, 4S, 5R, 6R)-5-acetamido-6-[(1S, 2R)-2-[(2S, 4S,
5R, 6R)-5-acetamido-2-carboxy-4-hydroxy-6-[(1R, 2R)-1, 2, 3-trihydroxypropyl] oxan-2-yl] …