Glioblastoma (GBM) is the most common high-grade primary malignant brain tumor with an
extremely poor prognosis. Given the poor survival with currently approved treatments for …

Oncolytic viruses (OVs) provide novel and promising therapeutic options for patients with
cancers resistant to traditional therapies. Natural or genetically modified OVs are …

Gliomas are intrinsic brain tumors that originate from neuroglial progenitor cells.
Conventional therapies, including surgery, chemotherapy, and radiotherapy, have achieved …

Glioma is the most common primary cancer of the central nervous system, and around 50%
of patients present with the most aggressive form of the disease, glioblastoma. Conventional …

Background Malignant glioma is the most common and lethal primary brain tumour, with
dismal survival rates and no effective treatment. We examined the safety and activity of NSC …

Oncolytic viruses represent a new class of therapeutic agents that promote anti-tumour
responses through a dual mechanism of action that is dependent on selective tumour cell …

Glioma is often referred to as one of the most dreadful central nervous system (CNS)-specific
tumors with rapidly-proliferating cancerous glial cells, accounting for nearly half of the brain …

Importance Oncolytic viruses (OVs) are emerging as important agents in cancer treatment.
Oncolytic viruses offer the attractive therapeutic combination of tumor-specific cell lysis …

Immune checkpoint inhibitors, including those targeting programmed cell death protein 1
(PD-1), are reshaping cancer therapeutic strategies. Evidence suggests, however, that tumor …

Gliomas are the most prevalent primary malignant brain tumors worldwide, with
glioblastoma (GBM) being the most common and aggressive type. Despite two decades of …