Removal of introns from messenger RNA precursors (pre-mRNA splicing) is an essential
step for the expression of most eukaryotic genes. Alternative splicing enables the regulated …

Aminoacyl-tRNA synthetases (ARSs) are essential enzymes for protein synthesis with
evolutionarily conserved enzymatic mechanisms. Despite their similarity across organisms …

Nontranslational functions of vertebrate aminoacyl tRNA synthetases (aaRSs), which
catalyze the production of aminoacyl-tRNAs for protein synthesis, have recently been …

Increases in S-nitrosylation and inactivation of the neuroprotective ubiquitin E3 ligase,
parkin, in the brains of patients with Parkinson's disease are thought to be pathogenic and …

Although key tumorigenic and tumor-suppressive factors have been unveiled over the last
several decades, cancer remains the most life-threatening disease. Multiomic analyses of …

With technological advancements, radiotherapy (RT) has become an effective non-surgical
treatment for hepatocellular carcinoma (HCC), comprehensively improving the local control …

Objective The majority of genes are alternatively spliced and growing evidence suggests
that alternative splicing is modified in cancer and is associated with cancer progression …

Aminoacyl-tRNA synthetases (ARSs) are an important class of enzymes with an
evolutionarily conserved mechanism for protein synthesis. In higher eukaryotic systems …

Aminoacyl-tRNA synthetases (ARSs) are essential enzymes that ligate amino acids to
tRNAs and translate the genetic code during protein synthesis. Their function in pathogen …

A tumorigenic factor, AIMP2 lacking exon 2 (AIMP2-DX2), is often upregulated in many
cancers. However, how its cellular level is determined is not understood. Here, we report …