The search for new, effective, and low-toxic anticancer agents is one of the most important
tasks of modern medicinal chemistry. In general, the solution to this problem comes down to …

Natural products are widely used as source for drugs development. An interesting example
is represented by natural drugs developed against human topoisomerase IB, a ubiquitous …

New palladium complexes with thiosemicarbazonate ligands derived from pyrene exhibit
potent antiproliferative activity against A2780 and cisplatin-resistant A2780Cis human …

Monolayer graphene field-effect sensors operating in liquid have been widely deployed for
detecting a range of analyte species often under equilibrium conditions. Here we report on …

A small library of benzimidazole-fused pyrrolo [3, 4-b] quinoline has been synthesized from
readily available benzimidazole 2-carbaldehyde and various substituted arylamines in good …

The topoisomerase I enzymatic inhibition of hybrid quinolino [4, 3-b](Siegel et al., 2013;
Antony et al., 2003)[1, 5] naphthyridines and quinolino [4, 3-b](Siegel et al., 2013; Antony et …

The ability of oxindolimine copper (ii) and zinc (ii) complexes, known to have antitumor
activity, to inhibit human topoisomerase IB has been tested through enzymatic kinetic assays …

Copper (II) and zinc (II) complexes with oxindolimine ligands, obtained by a condensation
reaction between isatin (1H-indole-2, 3-dione) and 2-(2-aminoethyl) pyridine, have been …

Abstract Camptothecin (CPT;(S)-(+)-4-ethyl-4-hydroxy-1H-pyrano [3', 4': 6, 7] indolizino [1, 2-
b] quinoline-3, 14-(4H, 12H)-dione) is a highly cytotoxic natural alkaloid that has not yet …

The human topoisomerase IB inhibition and the antiproliferative activity of 3-(4-
bromophenyl)-1-pyridin-2-ylprop-2-en-1-one thiosemicarbazone HPyCT4BrPh alone and its …