TFOS DEWS II pain and sensation report

C Belmonte, JJ Nichols, SM Cox, JA Brock, CG Begley… - The ocular …, 2017 - Elsevier
Pain associated with mechanical, chemical, and thermal heat stimulation of the ocular
surface is mediated by trigeminal ganglion neurons, while cold thermoreceptors detect …

Involvement of neural transient receptor potential channels in peripheral inflammation

HA Silverman, A Chen, NL Kravatz… - Frontiers in …, 2020 - frontiersin.org
Transient receptor potential (TRP) channels are a superfamily of non-selective cation
channels that act as polymodal sensors in many tissues throughout mammalian organisms …

Chronic stress followed by social isolation promotes depressive-like behaviour, alters microglial and astrocyte biology and reduces hippocampal neurogenesis in …

A Du Preez, D Onorato, I Eiben, K Musaelyan… - Brain, behavior, and …, 2021 - Elsevier
Unpredictable chronic mild stress (UCMS) is one of the most commonly used, robust and
translatable models for studying the neurobiological basis of major depression. Although the …

The aryl hydrocarbon receptor AhR links atopic dermatitis and air pollution via induction of the neurotrophic factor artemin

T Hidaka, E Ogawa, EH Kobayashi, T Suzuki… - Nature …, 2017 - nature.com
Atopic dermatitis is increasing worldwide in correlation with air pollution. Various organic
components of pollutants activate the transcription factor AhR (aryl hydrocarbon receptor) …

The neuropathic pain triad: neurons, immune cells and glia

J Scholz, CJ Woolf - Nature neuroscience, 2007 - nature.com
Nociceptive pain results from the detection of intense or noxious stimuli by specialized high-
threshold sensory neurons (nociceptors), a transfer of action potentials to the spinal cord …

The neuro-immune balance in neuropathic pain: involvement of inflammatory immune cells, immune-like glial cells and cytokines

PJ Austin, G Moalem-Taylor - Journal of neuroimmunology, 2010 - Elsevier
In a large proportion of individuals nervous system damage may lead to a debilitating
chronic neuropathic pain. Such pain may now be considered a neuro-immune disorder …

Nociceptors—noxious stimulus detectors

CJ Woolf, Q Ma - Neuron, 2007 - cell.com
Clinical pain is a serious public health issue. Treatment of pain-related suffering requires
knowledge of how pain signals are initially interpreted and subsequently transmitted and …

Transient receptor potential cation channels in disease

B Nilius, G Owsianik, T Voets… - Physiological …, 2007 - journals.physiology.org
The transient receptor potential (TRP) superfamily consists of a large number of cation
channels that are mostly permeable to both monovalent and divalent cations. The 28 …

Safety of autologous human schwann cell transplantation in subacute thoracic spinal cord injury

KD Anderson, JD Guest, WD Dietrich… - Journal of …, 2017 - liebertpub.com
The rationale for implantation of autologous human Schwann cells (SCs) in persons with
subacute spinal cord injury (SCI) is based on evidence that transplanted SCs are …

Perineural invasion and associated pain in pancreatic cancer

AA Bapat, G Hostetter, DD Von Hoff, H Han - Nature Reviews Cancer, 2011 - nature.com
Perineural invasion (PNI) is a prominent characteristic of pancreatic cancer. PNI is a process
whereby cancer cells invade the surrounding nerves, thus providing an alternative route for …