After years of extensive scientific discovery much has been learned about the networks that
regulate epithelial homeostasis. Loss of expression or functional activity of cell adhesion …

The correct establishment and maintenance of cell polarity are crucial for normal cell
physiology and tissue homeostasis. Conversely, loss of cell polarity, tissue disorganisation …

Epithelial–mesenchymal transition (EMT) is a reversible cellular process, characterized by
changes in gene expression and activation of proteins, favoring the trans-differentiation of …

Key events ranging from cell polarity to proliferation regulation to neuronal signaling rely on
the assembly of multiprotein adhesion or signaling complexes at particular subcellular sites …

The Scribble cell polarity module, comprising Scribbled (Scrib), Discs-large (Dlg) and Lethal-
2-giant larvae (Lgl), has a tumor suppressive role in mammalian epithelial cancers. The …

Disrupted cell polarity is a feature of epithelial cancers. The Crumbs, Par and Scribble
polarity complexes function to specify and maintain apical and basolateral membrane …

Loss of cellular polarity is a hallmark of epithelial cancers, raising the possibility that
regulators of polarity have a role in suppressing tumorigenesis. The Scribble complex is one …

The Scribble, Par and Crumbs modules were originally identified in the vinegar (fruit) fly,
Drosophila melanogaster, as being critical regulators of apico–basal cell polarity. In the …

Among the more than 160 PDZ containing proteins described in humans, the cytoplasmic
scaffold Scribble stands out because of its essential role in many steps of cancer …

SHOC2 is mutated in Noonan syndrome and plays a key role in the activation of the ERK-
MAPK pathway, which is upregulated in the majority of human cancers. SHOC2 functions as …