Chemotherapy resistance in advanced ovarian cancer patients

R Pokhriyal, R Hariprasad, L Kumar… - Biomarkers in …, 2019 - journals.sagepub.com
Ovarian cancer is the seventh most common gynaecologic malignancy seen in women.
Majority of the patients with ovarian cancer are diagnosed at the advanced stage making …

Meeting the challenge of ascites in ovarian cancer: new avenues for therapy and research

E Kipps, DSP Tan, SB Kaye - Nature Reviews Cancer, 2013 - nature.com
Malignant ascites presents a considerable clinical challenge to the management of ovarian
cancer, but also provides a wealth of opportunities for translational research. The …

Ovarian cancer, version 2.2020, NCCN clinical practice guidelines in oncology

DK Armstrong, RD Alvarez, JN Bakkum-Gamez… - Journal of the National …, 2021 - jnccn.org
Epithelial ovarian cancer is the leading cause of death from gynecologic cancer in the
United States and is the country's fifth most common cause of cancer mortality in women. A …

Olaparib tablets as maintenance therapy in patients with platinum-sensitive, relapsed ovarian cancer and a BRCA1/2 mutation (SOLO2/ENGOT-Ov21): a double-blind …

E Pujade-Lauraine, JA Ledermann, F Selle… - The lancet …, 2017 - thelancet.com
Background Olaparib, a poly (ADP-ribose) polymerase (PARP) inhibitor, has previously
shown efficacy in a phase 2 study when given in capsule formulation to all-comer patients …

[HTML][HTML] A phase 3 trial of bevacizumab in ovarian cancer

TJ Perren, AM Swart, J Pfisterer… - … England Journal of …, 2011 - Mass Medical Soc
Background Angiogenesis plays a role in the biology of ovarian cancer. We examined the
effect of bevacizumab, the vascular endothelial growth factor inhibitor, on survival in women …

Role of surgical outcome as prognostic factor in advanced epithelial ovarian cancer: a combined exploratory analysis of 3 prospectively randomized phase 3 …

A Du Bois, A Reuss, E Pujade‐Lauraine, P Harter… - Cancer, 2009 - Wiley Online Library
BACKGROUND: Primary surgery followed by platinum‐taxane based chemotherapy has
been the standard therapy in advanced ovarian cancer. However, the prognostic role of …

Survival impact of complete cytoreduction to no gross residual disease for advanced-stage ovarian cancer: a meta-analysis

SJ Chang, M Hodeib, J Chang, RE Bristow - Gynecologic oncology, 2013 - Elsevier
Objective To quantify the impact of complete cytoreduction to no gross residual disease on
overall survival among patients with advanced-stage ovarian cancer treated during the …

Dose-dense paclitaxel once a week in combination with carboplatin every 3 weeks for advanced ovarian cancer: a phase 3, open-label, randomised controlled trial

N Katsumata, M Yasuda, F Takahashi, S Isonishi… - The Lancet, 2009 - thelancet.com
Background Paclitaxel and carboplatin given every 3 weeks is standard treatment for
advanced ovarian carcinoma. Attempts to improve patient survival by including other drugs …

Evaluation of new platinum-based treatment regimens in advanced-stage ovarian cancer: a Phase III Trial of the Gynecologic Cancer Intergroup

MA Bookman, MF Brady, WP McGuire… - Journal of clinical …, 2009 - ascopubs.org
Purpose To determine if incorporation of an additional cytotoxic agent improves overall
survival (OS) and progression-free survival (PFS) for women with advanced-stage epithelial …

[HTML][HTML] The impact of second to sixth line therapy on survival of relapsed ovarian cancer after primary taxane/platinum-based therapy

LC Hanker, S Loibl, N Burchardi, J Pfisterer, W Meier… - Annals of oncology, 2012 - Elsevier
Background Despite recent progress in the treatment of ovarian cancer, the majority of
patients eventually relapse. There is little information on the effectiveness of chemotherapy …