Alzheimer's disease: from pathology to therapeutic approaches

R Jakob‐Roetne, H Jacobsen - … Chemie International Edition, 2009 - Wiley Online Library
Mind how you go: The current strategies for the development of therapies for Alzheimer's
disease are very diverse. Particular attention is given to the search for inhibitors (see picture …

Molecular and cellular aspects of protein misfolding and disease

E Herczenik, MFBG Gebbink - The FASEB Journal, 2008 - Wiley Online Library
Proteins are essential elements for life. They are building blocks of all organisms and the
operators of cellular functions. Humans produce a repertoire of at least 30,000 different …

The pentraxins 1975–2018: serendipity, diagnostics and drugs

MB Pepys - Frontiers in immunology, 2018 - frontiersin.org
The phylogenetically ancient, pentraxin family of plasma proteins, comprises C-reactive
protein (CRP) and serum amyloid P component (SAP) in humans and the homologous …

Complement component C1q inhibits β‐amyloid‐and serum amyloid P‐induced neurotoxicity via caspase‐and calpain‐independent mechanisms

K Pisalyaput, AJ Tenner - Journal of neurochemistry, 2008 - Wiley Online Library
Alzheimer's disease is a neurodegenerative disorder characterized by neuronal loss, β‐
amyloid (Aβ) plaques, and neurofibrillary tangles. Complement protein C1q has been found …

Serum amyloid P component accumulates and persists in neurones following traumatic brain injury

PK Yip, ZH Liu, S Hasan, MB Pepys… - Open …, 2023 - royalsocietypublishing.org
The mechanisms underlying neurodegenerative sequelae of traumatic brain injury (TBI) are
poorly understood. The normal plasma protein, serum amyloid P component (SAP), which is …

Genetic evidence for serum amyloid P component as a drug target in neurodegenerative disorders

AF Schmidt, C Finan, S Chopade… - Open …, 2024 - royalsocietypublishing.org
The mechanisms responsible for neuronal death causing cognitive loss in Alzheimer's
disease (AD) and many other dementias are not known. Serum amyloid P component (SAP) …

Molecular dissection of Alzheimer's disease neuropathology by depletion of serum amyloid P component

SE Kolstoe, BH Ridha, V Bellotti… - Proceedings of the …, 2009 - National Acad Sciences
New therapeutic approaches in Alzheimer's disease are urgently needed. The normal
plasma protein, serum amyloid P component (SAP), is always present in cerebrospinal fluid …

[HTML][HTML] Serum amyloid P component level is associated with clinical response to escitalopram treatment in patients with major depressive disorder

J Yang, J Zhou, J Zhou, H Wang, Z Sun, X Zhu… - Journal of Psychiatric …, 2022 - Elsevier
Serum amyloid P component (SAP) is a universal constituent of human amyloid deposits,
which has been implicated in Alzheimer's disease and major depressive disorder (MDD) …

TMT‐Based Proteomic Analysis of Plasma from Children with Rolandic Epilepsy

J Sun, T Jiang, F Gu, D Ma, J Liang - Disease Markers, 2020 - Wiley Online Library
Rolandic epilepsy is one of the most common epileptic syndromes in childhood. We used
TMT‐based proteomics and bioinformatics analysis to identify the differentially expressed …

Longitudinal protein changes in blood plasma associated with the rate of cognitive decline in Alzheimer's disease

M Sattlecker, M Khondoker, P Proitsi… - Journal of …, 2016 - journals.sagepub.com
Biomarkers of Alzheimer's disease (AD) progression are needed to support the development
of urgently needed disease modifying drugs. We employed a SOMAscan assay for …