The immunomodulatory drug fingolimod (FTY720, Gilenya R) was approved for oral
treatment of relapsing-remitting multiple sclerosis, due to its impressive efficacy and good …

Abstract Phospholipase A 2 (PLA 2) enzymes are involved in various inflammatory
pathological conditions including arthritis, cardiovascular and autoimmune diseases. The …

Altered epidermal differentiation along with increased keratinocyte proliferation is a
characteristic feature of psoriasis and pityriasis rubra pilaris (PRP). However, despite this …

Acute pancreatitis is a disease associated with suffering and high lethality. Although the
disease mechanism is unclear, phospholipase A2 (PLA2) produced by pancreatic acinar …

Abstract The World Health Organization recently listed snakebite envenoming as a
Neglected Tropical Disease, proposing strategies to significantly reduce the global burden …

Background Molecular mechanisms underlying inflammation-associated breast tumor
growth are poorly studied. S100A7, a pro-inflammatory molecule has been shown to …

The World Health Organization (WHO) recently added snakebite envenoming to the priority
list of Neglected Tropical Diseases (NTD). It is thought that~ 75% of mortality following …

ABSTRACT Phospholipase A2 (PLA2) enzymes are implicated in several pathological
conditions such as arthritis, cardiovascular diseases, and diabetes. It is highly important to …

Conspectus Water-soluble proteins as well as membrane-bound proteins associate with
membrane surfaces and bind specific lipid molecules in specific sites on the protein …

Abstract The Ca 2+-independent phospholipases, designated as group VI iPLA 2 s, also
referred to as PNPLAs due to their shared homology with patatin, include the β, γ, δ, ε, ζ, and …