This review focuses on the construction and application of structural chemokine receptor
models for the elucidation of molecular determinants of chemokine receptor modulation and …

Chemokines are pivotal players in instigation and perpetuation of synovitis through
leukocytes egress from the blood circulation into the inflamed articulation. Multitudinous …

A series of quinazolinone-derived inhibitors of the CXCR3 receptor have been synthesized
and their affinity for the receptor evaluated. Compounds were evaluated in a 125I-IP10 …

Background The CXCR3 receptor and its three interferon-inducible ligands (CXCL9,
CXCL10 and CXCL11) have been implicated as playing a central role in directing a Th1 …

Background: The first part of this two-part review discussed approaches to generating
antagonists for some of the CC chemokine receptors, including CCR1, CCR2, CCR3, and …

Chemokines and their receptors are known to play important roles in disease. More than 40
chemokine ligands and 20 chemokine receptors have been identified, but, to date, only two …

The central nervous system (CNS) is a highly complex tissue that is vital for a large number
of life-dependent processes. The neurons of the CNS are post-mitotic and cannot be easily …

CXCR3 and CCR5 are chemokine receptor that are predominantly expressed on the surface
of Th1 polarized T cells. In a variety of human and experimental autoimmune diseases the …

The CXCR3 chemokine receptor was first discovered in 1996 and has been shown to play
an important role in several diseases, most of which are related to inflammation. This review …

A linear quantitative structure–activity relationship (QSAR) model is presented for modeling
and predicting the inhibition of CXCR3 receptor. The model was produced by using the …