Non-coding RNAs in development and disease: background, mechanisms, and therapeutic approaches

J Beermann, MT Piccoli, J Viereck… - Physiological …, 2016 - journals.physiology.org
Advances in RNA-sequencing techniques have led to the discovery of thousands of non-
coding transcripts with unknown function. There are several types of non-coding linear …

Long noncoding RNAs as biomarkers in cancer

L Bolha, M Ravnik-Glavač, D Glavač - Disease markers, 2017 - Wiley Online Library
Long noncoding RNAs (lncRNAs) are a relatively well‐characterized class of noncoding
RNA (ncRNA) molecules, involved in the regulation of various cell processes, including …

Histone H3 trimethylation at lysine 36 guides m6A RNA modification co-transcriptionally

H Huang, H Weng, K Zhou, T Wu, BS Zhao, M Sun… - Nature, 2019 - nature.com
DNA and histone modifications have notable effects on gene expression. Being the most
prevalent internal modification in mRNA, the N 6-methyladenosine (m6A) mRNA …

METTL14 inhibits hematopoietic stem/progenitor differentiation and promotes leukemogenesis via mRNA m6A modification

H Weng, H Huang, H Wu, X Qin, BS Zhao, L Dong… - Cell stem cell, 2018 - cell.com
Summary N 6-methyladenosine (m 6 A), the most prevalent internal modification in
eukaryotic messenger RNAs (mRNAs), plays critical roles in many bioprocesses. However …

Revealing protein–lncRNA interaction

F Ferre, A Colantoni… - Briefings in …, 2016 - academic.oup.com
Long non-coding RNAs (lncRNAs) are associated to a plethora of cellular functions, most of
which require the interaction with one or more RNA-binding proteins (RBPs); similarly, RBPs …

TANRIC: an interactive open platform to explore the function of lncRNAs in cancer

J Li, L Han, P Roebuck, L Diao, L Liu, Y Yuan… - Cancer research, 2015 - AACR
Long noncoding RNAs (lncRNA) have emerged as essential players in cancer biology.
Using recent large-scale RNA-seq datasets, especially those from The Cancer Genome …

Long non-coding RNA: its evolutionary relics and biological implications in mammals: a review

JK Dhanoa, RS Sethi, R Verma, JS Arora… - Journal of animal …, 2018 - Springer
The central dogma of gene expression propounds that DNA is transcribed to mRNA and
finally gets translated into protein. Only 2–3% of the genomic DNA is transcribed to protein …

HMDD v2. 0: a database for experimentally supported human microRNA and disease associations

Y Li, C Qiu, J Tu, B Geng, J Yang, T Jiang… - Nucleic acids …, 2014 - academic.oup.com
Abstract The Human microRNA Disease Database (HMDD; available via the Web site at
http://cmbi. bjmu. edu. cn/hmdd and http://202.38. 126.151/hmdd/tools/hmdd2. html) is a …

lncRNAdb v2. 0: expanding the reference database for functional long noncoding RNAs

XC Quek, DW Thomson, JLV Maag… - Nucleic acids …, 2015 - academic.oup.com
Despite the prevalence of long noncoding RNA (lncRNA) genes in eukaryotic genomes,
only a small proportion have been examined for biological function. lncRNAdb, available at …

From discovery to function: the expanding roles of long noncoding RNAs in physiology and disease

M Sun, WL Kraus - Endocrine reviews, 2015 - academic.oup.com
Long noncoding RNAs (lncRNAs) are a relatively poorly understood class of RNAs with little
or no coding capacity transcribed from a set of incompletely annotated genes. They have …