Precocious puberty and other endocrine disorders during mitotane treatment for paediatric adrenocortical carcinoma–case series and literature review

E Moszczyńska, M Baszyńska-Wilk, A Tutka… - Pediatric Endocrinology …, 2024 - termedia.pl
Results The median age at the diagnosis of ACC was 1.5 years. All patients were treated
with surgery and mitotane, accompanied by chemotherapy regimens in 2 cases. The median …

[HTML][HTML] The effect of adjuvant mitotane therapy of the adrenocortical carcinoma on the endometrium and its clinical consequences in menstruating women. Literature …

P Szkodziak, F Szkodziak, A Korolczuk… - American Journal of …, 2024 - ncbi.nlm.nih.gov
Adrenocortical carcinoma (ACC) is a malignant tumour that originates from the adrenal
cortex. It is a highly aggressive cancer characterised by a poor prognosis with an annual …

Virtual screening of potential inhibitor against breast cancer-causing estrogen receptor alpha (ERα): molecular docking and dynamic simulations

S Muhammad, A Saba, RA Khera… - Molecular …, 2022 - Taylor & Francis
Breast cancer (Bca) causes the highest rate of mortality in females owing to the out-of-
control cell division in breast cells. In this work, we perform an in-silico screening based on …

Evaluation of the Therapeutic Effect of the Traditional Herbal Medicine Atrifil and Oshagh Gum on Testosterone‐Induced Benign Prostatic Hyperplasia in Wistar Rats

F Akbari, M Azadbakht, A Gaurav, F Azimi… - Advances in …, 2022 - Wiley Online Library
Benign prostatic hyperplasia (BPH) is a common disease that affects elderly men with
various complications. This study evaluates the effects of an Iranian traditional herbal …

Stimulated expression of CXCL12 in adrenocortical carcinoma by the PPARgamma ligand rosiglitazone impairs cancer progression

G Cantini, L Fei, L Canu, E Lazzeri, M Sottili… - Journal of Personalized …, 2021 - mdpi.com
Adrenocortical carcinoma (ACC) is a rare malignancy with poor prognosis when metastatic
and scarce treatment options in the advanced stages. In solid tumors, the chemokine …

International consensus on mitotane treatment in pediatric patients with adrenal cortical tumors: indications, therapy, and management of adverse effects

M Riedmeier, SRR Antonini… - European journal of …, 2024 - academic.oup.com
Objective Mitotane is an important cornerstone in the treatment of pediatric adrenal cortical
tumors (pACC), but experience with the drug in the pediatric age group is still limited and …

Exposure to anticancer drugs modulates the expression of ACSL4 and ABCG2 proteins in adrenocortical carcinoma cells

MAR Medrano, MM Bigi, PM Ponce, EJ Podesta… - Heliyon, 2023 - cell.com
Adrenocortical carcinoma (ACC) is a rare and malignant disease, with more than 50% of
patients developing hormone-secreting tumors. These tumors are genetically …

In Silico, In Vitro, and In Vivo Wound Healing Activity of Astragalus microcephalus Willd.

F Akbari, M Azadbakht, A Bagheri… - … in Pharmacological and …, 2022 - Wiley Online Library
Background and Objectives. A wound is one of the high‐prevalence disorders that affect
people's lives physically, mentally, and financially. This study examined the Astragalus …

[HTML][HTML] Human and Murine Cell Lines for Adrenocortical Carcinoma and Pheochromocytoma

E Luca, A Abate, K Wang, S Bornstein, S Sigala… - Endocrines, 2024 - mdpi.com
Adrenocortical carcinoma (ACC) and pheochromocytoma (PCC) are malignancies
originating from distinct layers of the adrenal gland. ACCs arise from the adrenal cortex, are …

Pubertal, Auxological, and Adult Height Outcomes in Children Treated for Adrenocortical Tumors: Half a Century Experience

FB Moletta, MCS Lobe, SN França… - Hormone Research in …, 2024 - karger.com
Introduction: Most children with adrenocortical tumors (ACTs) present with accelerated
growth and skeletal maturation at diagnosis, which potentially compromises their adult …