Over the past two decades there has been a great deal of interest in the development of
inhibitors of the cyclin-dependent kinases (CDKs). This attention initially stemmed from …

Hepatocellular carcinoma (HCC) is swiftly increasing in prevalence globally with a high
mortality rate. The progression of HCC in patients is induced with advanced fibrosis, mainly …

Cyclin-dependent kinases (CDKs) are proteins pivotal to a wide range of cellular functions,
most importantly cell division and transcription, and their dysregulations have been …

Cyclin-dependent kinases (CDK/Cyclins) form a family of heterodimeric kinases that play
central roles in regulation of cell cycle progression, transcription and other major biological …

Cyclin dependent kinase (CDK) inhibitors have been the topic of intense research for nearly
2 decades due to their widely varied and critical functions within the cell. Recently CDK9 has …

Background Cyclin-dependent kinase 9 (CDK9) stimulates oncogenic transcriptional
pathways in cancer and CDK9 inhibitors have emerged as promising therapeutic …

Despite surgical and chemotherapeutic advances over the past few decades, the prognosis
for ovarian cancer remains very poor. Although cyclin-dependent kinase (CDK) 9 has an …

Cyclin-dependent kinase 9 (CDK9) is a key transcriptional regulator and a lucrative target for
cancer treatment. Targeting CDK9 can effectively confine the hyperactivity of androgen …

Colorectal cancer (CRC) remains one of the most lethal human malignancies, and pursuit of
new therapeutic targets for treatment has been a major research focus. Cyclin‐dependent …

Cyclin dependent kinase 9 (CDK9) plays an essential role in regulating transcriptional
elongation. Aberrations in CDK9 activity have been observed in various cancers, which …