Folate being an important vitamin of B Complex group in our diet plays an important role not
only in the synthesis of DNA but also in the maintenance of methylation reactions in the …

TS is critical for providing the requisite nucleotide precursors in order to maintain DNA
synthesis and repair. Furthermore, it is an important target for several drugs such as 5 …

Acrylamide, a potential food carcinogen in humans, is biotransformed to the epoxide
glycidamide in vivo. Both acrylamide and glycidamide are conjugated with glutathione …

Methotrexate (MTX) is one of the staples of pediatric acute lymphoblastic leukemia (ALL)
treatment. MTX targets the folate metabolic pathway (FMP). Abnormal function of the …

There is substantial evidence that the decreased risk of lung cancer with high intake of
vegetables and fruits is linked to folate as a specific nutrient. Functional polymorphisms in …

Background Folate and homocysteine are involved in DNA synthesis and methylation
processes, which are deregulated during carcinogenesis. Objectives The aim of this study …

Genetic factors may contribute to individual differences in cancer susceptibility. This study
was designed to investigate the effects of the polymorphisms of methylenetetrahydrofolate …

Folate has been hypothesized to protect against aero-digestive cancers although the
evidence is not yet conclusive due to possible confounding by other dietary factors …

OBJECTIVE: To investigate the association between one-carbon metabolism and recurrent
pregnancy loss (RPL). One-carbon metabolism is important for maintaining pregnancy, and …

Aims: Genetic factors may contribute to individual differences in cancer susceptibility, drug
efficacy and toxicity. This study was designed to investigate the effects of the polymorphisms …