The retinoblastoma susceptibility gene (RB1) was the first tumor suppressor gene to be
molecularly defined. RB1 mutations occur in almost all familial and sporadic forms of …

Posttranslational modifications (PTMs) of proteins, the major mechanism of protein function
regulation, play important roles in regulating a variety of cellular physiological and …

Since the first report of p53 as a non-histone target of a histone acetyltransferase (HAT),
there has been a rapid proliferation in the description of new non-histone targets of HATs. Of …

The retinoblastoma (RB) tumour suppressor gene is functionally inactivated in a broad
range of paediatric and adult cancers, and a plethora of cellular functions and partners have …

Histone deacetylase inhibitors (HDACi) comprise structurally diverse compounds that are a
group of targeted anticancer agents. The first of these new HDACi, vorinostat …

This review focuses on the posttranslational acetylation of non-histone proteins, which
determines vital regulatory processes. The recruitment of histone acetyltransferases and …

Allostery is an intrinsic property of many globular proteins and enzymes that is
indispensable for cellular regulatory and feedback mechanisms. Recent theoretical and …

The retinoblastoma protein (pRB) and the pRB-related p107 and p130 comprise the 'pocket
protein'family of cell cycle regulators. These proteins are best known for their roles in …

Since the discovery of the retinoblastoma susceptibility gene (RB1) decades ago, RB1 has
been regarded as a prototype tumor suppressor gene providing a paradigm for tumor …

Over the last two decades, since the initial discovery of human papillomavirus (HPV) type 16
and 18 DNAs in cervical cancers by Dr. Harald zur Hausen (winner of the Nobel Prize in …