The principles and applications of avidin-based nanoparticles in drug delivery and diagnosis

A Jain, K Cheng - Journal of controlled release, 2017 - Elsevier
Avidin-biotin interaction is one of the strongest non-covalent interactions in the nature.
Avidin and its analogues have therefore been extensively utilized as probes and affinity …

Nanocarrier vaccines for SARS-CoV-2

J Machhi, F Shahjin, S Das, M Patel… - Advanced Drug Delivery …, 2021 - Elsevier
The SARS-CoV-2 global pandemic has seen rapid spread, disease morbidities and death
associated with substantive social, economic and societal impacts. Treatments rely on re …

Variant surface antigens of Plasmodium falciparum and their roles in severe malaria

M Wahlgren, S Goel, RR Akhouri - Nature Reviews Microbiology, 2017 - nature.com
Proliferation and differentiation inside erythrocytes are important steps in the life cycle of
Plasmodium spp. To achieve these, the parasites export polypeptides to the surface of …

Engineering virus-like particles as vaccine platforms

KM Frietze, DS Peabody, B Chackerian - Current opinion in virology, 2016 - Elsevier
Highlights•VLP have been engineered to improve their utility as vaccine platforms.•Targeted
engineering of VLPs has enhanced immunogenicity, stability, and versatility.•Predictive …

Bacterial superglue enables easy development of efficient virus-like particle based vaccines

S Thrane, CM Janitzek, S Matondo, M Resende… - Journal of …, 2016 - Springer
Abstract Background Virus-like particles (VLPs) represent a significant advance in the
development of subunit vaccines, combining high safety and efficacy. Their particulate …

New routes and opportunities for modular construction of particulate vaccines: stick, click, and glue

KD Brune, M Howarth - Frontiers in immunology, 2018 - frontiersin.org
Vaccines based on virus-like particles (VLPs) can induce potent B cell responses. Some non-
chimeric VLP-based vaccines are highly successful licensed products (eg, hepatitis B …

Escherichia coli-derived virus-like particles in vaccine development

X Huang, X Wang, J Zhang, N Xia, Q Zhao - npj Vaccines, 2017 - nature.com
Recombinant virus-like particle-based vaccines are composed of viral structural proteins
and mimic authentic native viruses but are devoid of viral genetic materials. They are the …

Synthetic biology for bioengineering virus‐like particle vaccines

HK Charlton Hume, J Vidigal… - Biotechnology and …, 2019 - Wiley Online Library
Vaccination is the most effective method of disease prevention and control. Many viruses
and bacteria that once caused catastrophic pandemics (eg, smallpox, poliomyelitis …

Perspectives on the technological aspects and biomedical applications of virus‐like particles/nanoparticles in reproductive biology: insights on the medicinal and …

V Chandrasekar, AV Singh… - Advanced …, 2022 - Wiley Online Library
Increasing data on the infection indicate that maternal infections are severe. Under the
realms of vaccine development, virus‐like particles (VLP)/nanoparticles (NPs) hold the …

Virus-like nanoparticles as a theranostic platform for cancer

KR Kim, AS Lee, SM Kim, HR Heo… - … in Bioengineering and …, 2023 - frontiersin.org
Virus-like nanoparticles (VLPs) are natural polymer-based nanomaterials that mimic viral
structures through the hierarchical assembly of viral coat proteins, while lacking viral …