Glucose is an important fuel for contracting muscle, and normal glucose metabolism is vital
for health. Glucose enters the muscle cell via facilitated diffusion through the GLUT4 glucose …

Few physiological parameters are more tightly and acutely regulated in humans than blood
glucose concentration. The major cellular mechanism that diminishes blood glucose when …

The heart is adapted to utilize all classes of substrates to meet the high-energy demand, and
it tightly regulates its substrate utilization in response to environmental changes. Although …

Glucose is the major energy source for mammalian cells as well as an important substrate
for protein and lipid synthesis. Mammalian cells take up glucose from extracellular fluid into …

Thyroid hormones (TH) are crucial for development, growth, differentiation, metabolism and
thermogenesis. Skeletal muscle (SM) contractile function, myogenesis and bioenergetic …

OBJECTIVE—Insulin resistance associated with obesity and diabetes is ameliorated by
specific overexpression of GLUT4 in skeletal muscle. The molecular mechanisms regulating …

Mitofusin 2 (Mfn2) is a mitochondrial membrane protein that participates in mitochondrial
fusion and regulates mitochondrial metabolism in mammalian cells. Here, we show that …

Glucose is used aerobically and anaerobically to generate energy for cells. Glucose
transporters (GLUTs) are transmembrane proteins that transport glucose across the cell …

The heart is a unique organ in many ways. It consists of specialized muscle cells
(cardiomyocytes), which are adapted to contract constantly in a coordinated fashion. This is …

Skeletal muscle is a major glucose‐utilizing tissue in the absorptive state and the major
glucose transporter expressed in muscle in adulthood is GLUT4. GLUT4 expression is …