Industrial biotechnology can lead to new routes and potentially to more sustainable
production of numerous chemicals. We review the potential of biobased routes from sugars …

Robust systematic approaches for the metabolic engineering of cell factories remain elusive.
The available models for predicting phenotypical responses and mechanisms are …

Background Industrial biotechnology will play an increasing role in creating a more
sustainable global economy. For conventional aerobic bioprocesses supplying O 2 can …

Urothelium is a transitional, stratified epithelium that lines the lower urinary tract, providing a
tight barrier to urine whilst retaining the capacity to stretch and rapidly resolve damage. The …

Lipids play a crucial role in signaling and metabolism, regulating the development and
maintenance of the skeleton. Membrane lipids have been hypothesized to act as …

Cyanobacteria have long been suggested as an industrial chassis for the conversion of
carbon dioxide to products as part of a circular bioeconomy. The slow growth, carbon …

Abstract Background The filamentous fungus Aspergillus niger is frequently used for
industrial production of fermentative products such as enzymes, proteins and biochemicals …

Citramalic acid (citramalate) is important for the chemical synthesis of methylmethacrylate, a
bulk monomer used for manufacturing biodegradable polymers. Escherichia coli strains …

Pitayas are rich in organic acids, especially citramalic acid, which is significantly higher than
the plants. However, the mechanism of citramalic acid biosynthesis remains to be fully …

We demonstrate the use of two-stage dynamic metabolic control to manipulate feedback
regulation in central metabolism and improve stationary phase biosynthesis in engineered …