β-arrestins are versatile adapter proteins that form complexes with most G-protein-coupled
receptors (GPCRs) following agonist binding and phosphorylation of receptors by G-protein …

G protein-coupled receptor (GPCR) kinases (GRKs) are best known for their role in
homologous desensitization of GPCRs. GRKs phosphorylate activated receptors and …

This review is provided in recognition of the extensive contributions of Dr. Robert J.
Lefkowitz to the G protein-coupled receptor (GPCR) field and to celebrate his 75th birthday …

In the classical model of G-protein-coupled receptor (GPCR) regulation, arrestins terminate
receptor signalling. After receptor activation, arrestins desensitize phosphorylated GPCRs …

The basis of the duplex theory of vision is examined in view of the dazzling array of data on
visual pigment sequences and the pigments they form, on the microspectrophotometry …

▪ Abstract Visual transduction captures widespread interest because its G-protein signaling
motif recurs throughout nature yet is uniquely accessible for study in the photoreceptor cells …

G protein-coupled receptors (GPCRs) are important regulators of various cellular functions
via activation of intracellular signaling events. Active GPCR signaling is shut down by GPCR …

Cell migration is a fundamental biological process involved in normal physiology. Altered
motile phenotypes are however often associated with the development and progression of …

The β2 adrenergic receptor (β2AR) undergoes desensitization by a process involving its
phosphorylation by both protein kinase A (PKA) and G protein-coupled receptor kinases …

It is well established that the function of most heptahelical receptors (seven-transmembrane-
span receptors; 7TMRs) is tightly regulated by the desensitizing actions of arrestins …