Synthesis, protolytic equilibria, and antimicrobial action of nifuroxazide analogs

GA Gamov, AN Kiselev, AE Murekhina… - Journal of Molecular …, 2021 - Elsevier
The present paper reports on the synthesis of four hydrazones derived from 5-nitro-2-
furfural, 5-nitro-2-thiophenal, isoniazid, 2, 4-and 3, 4-dihydroxy-N …

Development of a cell-based alphaLISA assay for high-throughput screening for small molecule proteasome modulators

SD Staerz, EM Lisabeth, E Njomen, TS Dexheimer… - ACS …, 2023 - ACS Publications
The balance between protein degradation and protein synthesis is a highly choreographed
process generally called proteostasis. Most intracellular protein degradation occurs through …

A combined experimental and theoretical study of nitrofuran antibiotics: crystal structures, DFT computations, sublimation and solution thermodynamics

AN Manin, KV Drozd, AP Voronin, AV Churakov… - Molecules, 2021 - mdpi.com
Single crystal of furazolidone (FZL) has been successfully obtained, and its crystal structure
has been determined. Common and distinctive features of furazolidone and nitrofurantoin …

Polymorphism and molecular conformations of nicosulfuron: structure, properties and desolvation process

Y Liu, L Jia, S Wu, S Xu, X Zhang, S Jiang, J Gong - CrystEngComm, 2019 - pubs.rsc.org
Four new solvent-free forms and five solvates of the widely-used herbicide nicosulfuron
were found. The crystal structures of the reported form II and two new solvates (methanol …

Versatile solid forms of boscalid: insight into the crystal structures and phase transformations

Z Li, L Jia, P Shi, S Jiang, J Gong, S Wu - CrystEngComm, 2019 - pubs.rsc.org
Boscalid, a commonly used fungicide, is mainly used for controlling gray mold, powdery
mildew, and sclerotia. The aim of this study was to investigate the solid forms of boscalid …

Screening a small hydrazide-hydrazone combinatorial library for targeting the STAT3 in monocyte-macrophages with insulated reporter transposons

VV Mossine, SP Kelley, JK Waters… - Medicinal Chemistry …, 2023 - Springer
Abstract The Signal Transducer and Activator of Transcription 3 (STAT3) pharmacological
targeting is regarded as a prospective approach to treat cancer, autoimmune disorders, or …

[PDF][PDF] Polymorphism of the dinuclear CoIII–Schiff base complex [Co2 (o-van-en) 3]· 4CH3CN (o-van-en is a salen-type ligand)

A Vráblová, J Černák, LR Falvello… - … Section C: Structural …, 2019 - journals.iucr.org
Reactions of Co (OH) 2 with the Schiff base bis (2-hydroxy-3-methoxybenzylidene)
ethylenediamine, denoted H2 (o-van-en), under different conditions yielded the previously …

[HTML][HTML] ТЕРМОДИНАМИКА РЕАКЦИЙ МЕЖМОЛЕКУЛЯРНЫХ ВЗАИМОДЕЙСТВИЙ БИОМОЛЕКУЛ В ВОДЕ И ВОДНО-ОРГАНИЧЕСКИХ РАСТВОРИТЕЛЯХ

ТР Усачева, ГА Гамов, НН Куранова… - … заведений. Химия и …, 2023 - cyberleninka.ru
Приведено обобщение собственных результатов исследований реакций образования
молекулярных комплексов циклодекстринов с биологически активными …

Discovery and Design of Novel 20S Proteasome Activators for Targeted Protein Degradation and Their Evaluation in Neurodegeneration Models

SD Staerz - 2024 - search.proquest.com
In cells, proteostasis is a constant and highly choreographed process that maintains a
balance between the synthesis and degradation of proteins. The ubiquitin-proteasome …

Exploratory Study on Lercanidipine Hydrochloride Polymorphism: pH-Dependent Solubility Behavior and Simulation of its Impact on Pharmacokinetics

IA Repin, R Loebenberg, J DiBella, ACL Conceição… - AAPS …, 2021 - Springer
This work describes an exploratory experimental and in silico study of the influence of
polymorphism, particle size, and physiology on the pharmacokinetics of lercanidipine …