Sepsis is a systemic inflammatory response syndrome with high morbidity and mortality
mediated by infection‐caused oxidative stress. Early antioxidant intervention by removing …

Simple Summary Grimace scales for laboratory animals were first reported ten years ago.
Yet, despite their promise as pain assessment tools it appears that they have not been …

Sepsis-associated encephalopathy (SAE) is one of the most common types of organ
dysfunction without overt central nervous system (CNS) infection. It is associated with higher …

Background: The high-density lipoprotein hypothesis of atherosclerosis has been
challenged by clinical trials of cholesteryl ester transfer protein (CETP) inhibitors, which …

Carbapenemase-producing Enterobacterales (CPE) are spreading rapidly in hospital
settings. Asymptomatic CPE gut colonisation may be associated with dysbiosis and gut-lung …

Cancer patients often die from symptoms that manifest at a distance from any tumor.
Mechanisms underlying these systemic physiological perturbations, called paraneoplastic …

Anecdotal clinical reports suggested a benefit of adjunct immune checkpoint inhibitors (ICIs)
to treat invasive mucormycosis. However, proof-of-concept data in animal models and …

Objective: Atherosclerosis predominantly forms in regions of oscillatory shear stress while
regions of laminar shear stress are protected. This protection is partly through the …

Candida auris is a globally spreading yeast pathogen causing bloodstream infections with
high mortality in critically ill patients. The inherent antifungal drug resistance of most C. auris …

Targeting single mediators has failed to reduce the mortality of sepsis. We developed a
telodendrimer (TD) nanotrap (NT) to capture various biomolecules via multivalent, hybrid …