Alzheimer disease (AD) is the most common form of neurodegenerative disease, estimated
to contribute 60–70% of all cases of dementia worldwide. According to the prevailing …

Neuroimaging has made it possible to measure pathological brain changes associated with
Alzheimer's disease (AD) in vivo. Over the past decade, these measures have been …

Abstract Alzheimer's disease (AD), being the number one in terms of dementia burden, is an
insidious age-related neurodegenerative disease and is presently considered a global …

Brain network dysfunction is increasingly recognised in Alzheimer's disease (AD). However,
the causes of brain connectivity disruption are still poorly understood. Recently …

Microglia are the primary immune cell of the brain and function to protect the central nervous
system (CNS) from injury and invading pathogens. In the homeostatic brain, microglia serve …

Alzheimer's disease (AD) is the leading cause of dementia in elderly people. The etiology of
this disease remains a matter of intensive research in many laboratories. We have advanced …

In vivo exploration of activated microglia in neurodegenerative diseases is achievable by
Positron Emission Tomography (PET) imaging, using dedicated radiopharmaceuticals …

Over the past several years, there has been a surge in blood biomarker studies examining
the value of plasma or serum neurofilament light (NfL) as a biomarker of neurodegeneration …

Abstract Chitinase 3-like 1 (CHI3L1) is a secreted glycoprotein that mediates inflammation,
macrophage polarization, apoptosis, and carcinogenesis. The expression of CHI3L1 is …

Alzheimer's disease (AD) is a multifactorial age-related brain disease. Numerous
pathological events run forth in the brain leading to AD. There is an initial long, dormant …