Bone fracture is a very common body injury. The healing process is physiologically complex,
involving both biological and mechanical aspects. Following a fracture, cell migration …

This paper aims to provide useful and practical information on the design of composite
prostheses for healing bone fractures and describes the material properties of living tissues …

Techniques of bone reconstructive surgery are largely based on conventional, non-cell-
based therapies that rely on the use of durable materials from outside the patient's body. In …

Biodegradable scaffolds play a critical role in therapeutic tissue engineering, in which the
matrix degradation and tissue ingrowth are of particular importance for determining the …

The concept of using stem cells as self-renewing sources of healthy cells in regenerative
medicine has existed for decades, but most applications have yet to achieve clinical …

After trauma, fractured bone starts healing directly through bone union or indirectly through
callus formation process. Intramembranous and endochondral ossification are two …

Large bone defects are clinically challenging, with up to 15% of these requiring surgical
intervention due to non-union. Bone grafts (autographs or allografts) can be used but they …

Mechanobiological models have previously been used to predict the time course of the
tissue differentiation process, with the local mechanical environment as the regulator of cell …

Large segmental bone defects represent a clinical challenge for which current treatment
procedures have many drawbacks. 3D-printed scaffolds may help to support healing, but …

Large bone defects represent a clinical challenge for which the implantation of scaffolds
appears as a promising strategy. However, their use in clinical routine is limited, in part due …